مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

172
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

92
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats

Pages

  152-160

Abstract

 Objective: Diabetes is associated with vascular complications and impaired Angiogenesis. Since Angiogenesis plays a crucial role in vascular homeostasis in ischemic heart diseases, in this study, the effect of IMOD™ on MiR-503 and CDC25 expression level which are altered in impaired Angiogenesis were investigated in heart tissue of diabetic rats. Materials and Methods: Forty male Wistar rats (200-250 g) were randomly classified into 4 groups: control (C), IMOD™ (I), Diabetes (D), and Diabetes+IMOD™ (D+I). For induction of experimental Diabetes in animals, a single dose of streptozotocin (STZ; 60mg/kg) was injected intraperitoneally. After 8 weeks of treatment with IMOD™ (20 mg/kg/day), heart tissue samples were removed and used for measurement of MiR-503 and CDC25 expression level as well as histological studies. Results: Results of this study showed that Diabetes decreased heart tissue Angiogenesis which was associated with increased MiR-503 and reduced CDC25 expression levels (p<0. 05) and IMOD™ could reduce the expression of MiR-503 and increase the expression of CDC25 (p<0. 05). Moreover, IMOD™ extensively induced Angiogenesis in the heart tissue of diabetic group. However, IMOD™ had no significant effect on expressions of MiR-503 and CDC25, or Angiogenesis in healthy rats. Conclusion: This study showed that IMOD™ is able to increase Angiogenesis in the heart tissue of diabetic rats. The angiogenic effect of IMOD™ is associated with reduction of MiR-503 expression and increased expression of CDC25.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Ghaffari Nasab, Arshad, Mirzaie Bavil, Fariba, Ghiasi, Rafigheh, SADIGH ETEGHAD, SAEED, & ALIPOUR, MOHAMMAD REZA. (2018). Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 8(2), 152-160. SID. https://sid.ir/paper/326457/en

    Vancouver: Copy

    Ghaffari Nasab Arshad, Mirzaie Bavil Fariba, Ghiasi Rafigheh, SADIGH ETEGHAD SAEED, ALIPOUR MOHAMMAD REZA. Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2018;8(2):152-160. Available from: https://sid.ir/paper/326457/en

    IEEE: Copy

    Arshad Ghaffari Nasab, Fariba Mirzaie Bavil, Rafigheh Ghiasi, SAEED SADIGH ETEGHAD, and MOHAMMAD REZA ALIPOUR, “Effects of IMOD™ on angiogenesis, miR-503 and CDC25 expression levels in heart tissue of diabetic male rats,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 8, no. 2, pp. 152–160, 2018, [Online]. Available: https://sid.ir/paper/326457/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button