Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors

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Forouzanfar Fatemeh; Ghazavi Hamed; Vahedi Mohammad Mahdi; Tarrah Kimia; YAVARI ZAHRA; HOSSEINI AZAR; Aghaee Azita; RAKHSHANDEH HASSAN

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Journal: Avicenna Journal of Phytomedicine Year:2020 | Volume:10 | Issue:1 Page(s): 70-77

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Title

Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors

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Keywords

Pentobarbital

PC12

Sleep

Tanacetum parthenium

Herbal medicine

Abstract

Objective: Sleep disorders are among the most common psychiatric and medical conditions. In the present study, the hypnotic effect of Tanacetum parthenium was studied in mice. Materials and Methods: The hydro-alcoholic extract (HAE) of T. parthenium and three fractions of it, namely water fraction (WF), ethyl acetate fraction (EAF), and n-hexane fraction (NHF), were intraperitoneally (ip) administrated to mice 30 min before injection of sodium Pentobarbital (30 mg/kg, ip). Then, 30 min after administration of HAE, motor coordination (rota-rod test) was evaluated. Besides, LD50 of HAE was determined and the cytotoxicity of HAE was evaluated in PC12 cells using the MTT assay. Results: HAE 50-200 mg/kg increased the Sleeping time. EAF was the only fraction which could prolong the Sleep duration and decrease Sleep latency. The LD50 value was 4. 8 g/kg. The extract induced no cytotoxic effects in PC12 cell line. Conclusion: The results suggested that T. parthenium potentiates Pentobarbital hypnosis without causing toxic effects. Probably, its effects are mediated by the components present in EAF of this plant.

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APA: Copy

Forouzanfar, Fatemeh, Ghazavi, Hamed, Vahedi, Mohammad Mahdi, Tarrah, Kimia, YAVARI, ZAHRA, HOSSEINI, AZAR, Aghaee, Azita, & RAKHSHANDEH, HASSAN. (2020). Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(1), 70-77. SID. https://sid.ir/paper/326471/en

Vancouver: Copy

Forouzanfar Fatemeh, Ghazavi Hamed, Vahedi Mohammad Mahdi, Tarrah Kimia, YAVARI ZAHRA, HOSSEINI AZAR, Aghaee Azita, RAKHSHANDEH HASSAN. Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(1):70-77. Available from: https://sid.ir/paper/326471/en

IEEE: Copy

Fatemeh Forouzanfar, Hamed Ghazavi, Mohammad Mahdi Vahedi, Kimia Tarrah, ZAHRA YAVARI, AZAR HOSSEINI, Azita Aghaee, and HASSAN RAKHSHANDEH, “Tanacetum parthenium enhances pentobarbital-induced sleeping behaviors,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 1, pp. 70–77, 2020, [Online]. Available: https://sid.ir/paper/326471/en

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