Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

236
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

224
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Pomegranate peel extract inhibits internalization and replication of the influenza virus: An in vitro study

Pages

  143-151

Abstract

 Objective: Influenza virus, which is associated with high level of morbidity and mortality, has been recently considered a public health concern; however, the methods of choice to control and treat it are limited. Our previous study showed Anti-influenza virus activity of Pomegranate peel extract (PPE). In this study, the mechanism through which PPE acts against influenza virus A/Puerto Rico/8/34 (H1N1; PR8) was investigated. Materials and Methods: Ethyl alcohol extract of Pomegranate (Punica granatum L. ) peel was prepared, and the action mechanism of PPE in inhibiting influenza replication was studied by time-of-drug-addition assay, virucidal activity, RNA replication, hemagglutination inhibition assay, viral mRNA expression, and western blot analysis. Results: PPE inhibited viral polymerase activity, viral RNA replication, and viral protein expression but could not affect hemagglutination inhibition and virucidal activity. According to time-of-drug-addition assay results, PPE inhibited the virus adsorption and early steps of influenza replication. Conclusion: This study demonstrated that the antiviral effect of PPE on influenza virus is most probably associated with inhibition of viral adsorption and viral RNA transcription.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    Moradi, Mohammad Taghi, KARIMI, ALI, RAFIEIAN KOPAEI, MAHMOUD, Rabiei Faradonbeh, Mohammad, & MOMTAZ, HASSAN. (2020). Pomegranate peel extract inhibits internalization and replication of the influenza virus: An in vitro study. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 10(2), 143-151. SID. https://sid.ir/paper/326486/en

    Vancouver: Copy

    Moradi Mohammad Taghi, KARIMI ALI, RAFIEIAN KOPAEI MAHMOUD, Rabiei Faradonbeh Mohammad, MOMTAZ HASSAN. Pomegranate peel extract inhibits internalization and replication of the influenza virus: An in vitro study. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2020;10(2):143-151. Available from: https://sid.ir/paper/326486/en

    IEEE: Copy

    Mohammad Taghi Moradi, ALI KARIMI, MAHMOUD RAFIEIAN KOPAEI, Mohammad Rabiei Faradonbeh, and HASSAN MOMTAZ, “Pomegranate peel extract inhibits internalization and replication of the influenza virus: An in vitro study,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 10, no. 2, pp. 143–151, 2020, [Online]. Available: https://sid.ir/paper/326486/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top