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Information Journal Paper

Title

Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial

Pages

  44-53

Abstract

 Objective: To study the blood pressure, lipid and glycemic effects and safety of Vaccinium arctostaphylos leaf in the hypertensive hyperlipidemic type 2 diabetic patients. Materials and Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoint, systolic and diastolic blood pressures and blood levels of fasting glucose (FG), 2-hr postprandial glucose (2hPPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), LDL-C, triglyceride, HDL-C, SGOT, SGPT and creatinine were determined in both groups. To evaluate the extract safety, serum SGOT, SGPT and creatinine levels were tested; also, the patients were requested to report any adverse effects. Results: FG, 2hPPG, HbA1c, TC, LDL-C, triglyceride and systolic and diastolic blood pressures were decreased, whereas HDL-C was increased significantly in the extract group compared to those of the placebo group at the endpoint (for all cases, p<0. 05). The extract did not significantly influence other parameters and no adverse effects were reported. Conclusion: V. arctostaphylos leaf hydro-alcoholic extract as an adjunct to the conventional drugs has additional antihypertensive as well as anti-dyslipidemic and anti-hyperglycemic effects in hypertensive hyperlipidemic type 2 diabetic patients. Besides, the extract lacks hepatic, renal and patient-reported adverse effects.

Cites

References

Cite

APA: Copy

MOHTASHAMI, REZA, Fallah Hoseini, Hasan, NABATI, FARZANEH, HAJIAGHAEE, REZA, & Kianbakht, Saeed. (2019). Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(1), 44-53. SID. https://sid.ir/paper/326499/en

Vancouver: Copy

MOHTASHAMI REZA, Fallah Hoseini Hasan, NABATI FARZANEH, HAJIAGHAEE REZA, Kianbakht Saeed. Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(1):44-53. Available from: https://sid.ir/paper/326499/en

IEEE: Copy

REZA MOHTASHAMI, Hasan Fallah Hoseini, FARZANEH NABATI, REZA HAJIAGHAEE, and Saeed Kianbakht, “Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 1, pp. 44–53, 2019, [Online]. Available: https://sid.ir/paper/326499/en

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