Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of Semenovia suffruticosa

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SOLTANI SARA; MOHAMADI NEDA; RAJAEI PEYMAN; KHODAMI MOJTABA; MOHAMMADI MEHDI

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Journal: Avicenna Journal of Phytomedicine Year:2019 | Volume:9 | Issue:2 Page(s): 143-152

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Information Journal Paper

Title

Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of Semenovia suffruticosa

Author(s)

Keywords

Semenovia suffruticosa

Essential oil

Methanol extract

Antioxidant and cytotoxic

properties

Antibacterial activity

Abstract

Objective: In this study, our aim was to extract, and identify and quantify the chemical composition of Essential oils of Semenovia suffruticosa grown in Kerman, Iran. Moreover, cytotoxic, antioxidant and antimicrobial activity of the Essential oil and Methanol extract of aerial parts of S. suffruticosa were reported. Materials and Methods: GC and GC/MS analysis were used for identifying and quantifying the Essential oil components. Antioxidant and Antibacterial activity were tested by 2, 2-diphenyl1-picrylhydrazyl (DPPH) and agar disc diffusion methods, respectively and MTT assay was used to determine the antiproliferative potential of the oil against breast (MCF-7), colon (HT-29), neuroblastoma (SH-SY5Y), embryonal carcinoma (NCCIT) cancer cell relative to human umbilical vein endothelial cell (HUVEC) as a normal cell. Apoptosis induction was monitored by ﬂ ow cytometry using PE annexin V apoptosis detection kit and cell cycle arrest was by with propidium iodide. Results: Z-β-ocimene (25. 1%), linalool (17. 8%) and β-bisabolol (13. 3%) were recognized as major components of the Essential oil. Our study demonstrated apoptosis-inducing potential of Essential oil on normal and cancer cells. However, Methanol extract exerted cytotoxicity against a number of cancer cells and arrested cancer cells in G2/M phase; nevertheless, it did not exert strong cytotoxicity against normal cells. Furthermore, DPPH and disc diffusion results showed that while Essential oil has considerable antiradical activity, Methanol extract did not exert promising antioxidant and antimicrobial activity. Conclusion: Methanol extract of S. suffruticosa shows tumor-cellspecific cytotoxic properties and the Essential oil demonstrated a strong antioxidant activity.

Cites

References

Essential oil constituents and biological activities of leaf extracts of Semenovia suffruticosa from Iran

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APA: Copy

SOLTANI, SARA, MOHAMADI, NEDA, RAJAEI, PEYMAN, KHODAMI, MOJTABA, & MOHAMMADI, MEHDI. (2019). Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of Semenovia suffruticosa. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(2), 143-152. SID. https://sid.ir/paper/326503/en

Vancouver: Copy

SOLTANI SARA, MOHAMADI NEDA, RAJAEI PEYMAN, KHODAMI MOJTABA, MOHAMMADI MEHDI. Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of Semenovia suffruticosa. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(2):143-152. Available from: https://sid.ir/paper/326503/en

IEEE: Copy

SARA SOLTANI, NEDA MOHAMADI, PEYMAN RAJAEI, MOJTABA KHODAMI, and MEHDI MOHAMMADI, “Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of Semenovia suffruticosa,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 2, pp. 143–152, 2019, [Online]. Available: https://sid.ir/paper/326503/en

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