مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

128
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

102
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Interactive anticancer effect of nanomicellar curcumin and galbanic acid combination therapy with some common chemotherapeutics in colon carcinoma cells

Pages

  237-247

Abstract

 Objective: In the current investigation, we aimed to study the combined cytotoxicity of curcumin, as a nanomicellar formulation, and Galbanic acid (Gal), dissolved in DMSO against the murine C26 and human Caco-2 colon carcinoma cells. Further, curcumin potential for Cisplatin and doxorubicin (Dox) co-therapy was studied. Materials and Methods: The combined cytotoxic effect of these phytochemicals at varying dose ratios were examined using the MTT colorimetric assay. Moreover, the time-dependent toxicity of curcumin, Cisplatin, Dox, and pegylated liposomal Dox (Doxil) was determined. The interactive anti-proliferative behavior of these compounds was examined using the CompuSyn software. Results: Nanomicellar curcumin showed considerable cytotoxicity in C26 cells 24 hr post-treatment. Co-treatment of cells with curcumin nanomicelles: Gal had a synergistic effect in C26 (at 10: 1 molar ratio), and Caco-2 (at 1: 5 molar ratio) cell lines in cell cultures. Nanomicellar curcumin showed strong and mild synergistic inhibitory effects in C26 cells when co-administered with Doxil and Cisplatin, respectively. Conclusion: Curcumin nanomicelles and Gal had a synergistic effect in C26 and Caco-2 cell lines. It is speculated that Nanomicellar curcumin shows synergistic cancer cell killing if administered 24-hr post-injection of Doxil and Cisplatin.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    JAFARI, ARASH, Teymouri, Manouchehr, Ebrahimi Nik, Maryam, ABBASI, AZAM, IRANSHAHI, MEHRDAD, Hanafi Bojd, Mohamad Yahya, & JAFARI, MAHMOUD REZA. (2019). Interactive anticancer effect of nanomicellar curcumin and galbanic acid combination therapy with some common chemotherapeutics in colon carcinoma cells. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(3), 237-247. SID. https://sid.ir/paper/326509/en

    Vancouver: Copy

    JAFARI ARASH, Teymouri Manouchehr, Ebrahimi Nik Maryam, ABBASI AZAM, IRANSHAHI MEHRDAD, Hanafi Bojd Mohamad Yahya, JAFARI MAHMOUD REZA. Interactive anticancer effect of nanomicellar curcumin and galbanic acid combination therapy with some common chemotherapeutics in colon carcinoma cells. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(3):237-247. Available from: https://sid.ir/paper/326509/en

    IEEE: Copy

    ARASH JAFARI, Manouchehr Teymouri, Maryam Ebrahimi Nik, AZAM ABBASI, MEHRDAD IRANSHAHI, Mohamad Yahya Hanafi Bojd, and MAHMOUD REZA JAFARI, “Interactive anticancer effect of nanomicellar curcumin and galbanic acid combination therapy with some common chemotherapeutics in colon carcinoma cells,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 3, pp. 237–247, 2019, [Online]. Available: https://sid.ir/paper/326509/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button