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Information Journal Paper

Title

Evaluation of the protective and therapeutic effects of Pistacia atlantica gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice

Pages

  248-259

Abstract

 Objective: The purpose of this study was to investigate the protective and therapeutic effects of aqueous extract of P. atlantica gum on an experimental Asthma in BALB/c mice. Materials and Methods: Aqueous extract of dried and milled P. atlantica gum was assemble and evaluate by GC-MS. In order to investigate the effect of P. atlantica gum extract on cellular and pathological aspects of Asthma, 60 BALB/c mice were divided into six groups as: negative control, Asthmatic group, Asthmatic group receiving dexamethasone (1mg/kg; intraperitoneal (IP)) and three Asthmatic groups receiving different concentrations of the extract (100, 200 and 400 mg/kg, orally) from the beginning of the study and continued for 84 days. The examined parameters included cell population, IgE antibody production, levels of IL-4, IL-5, TGF-β , INF-γ , IL-10, and IL-17 cytokines, and lung tissue damage. Results: Regardless of the dose, aqueous extract of P. atlantica gum, caused significant decrease in the number of BALF eosinophilic cells and levels of anti-ovalbumin IgE, IL-4, IL-5 and IL-17 cytokine levels, as well as pathologic damage of the lung tissue. In addition, the amount of anti-inflammatory IL-10, TGF-β , and INF-γ Th1 cytokines significantly increased in the extracttreated groups compared to the Asthmatic and dexamethasonetreated groups. Moreover, IFN-γ /IL-4 ratio significantly increased in a dose-dependent manner compared to the un-treated Asthma group. Conclusion: The aqueous extract of P. atlantica gum can be considered as a potent anti-inflammatory and immunomodulatory compound and may be used as a natural compound for treatment of immune system disorders.

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    APA: Copy

    Shakarami, Zaynab, ESMAEILI GOUVARCHIN GHALEH, HADI, MANSOURI MOTLAGH, BAHMAN, SHEIKHIAN, ALI, & JALALI KONDORI, BAHMAN. (2019). Evaluation of the protective and therapeutic effects of Pistacia atlantica gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(3), 248-259. SID. https://sid.ir/paper/326512/en

    Vancouver: Copy

    Shakarami Zaynab, ESMAEILI GOUVARCHIN GHALEH HADI, MANSOURI MOTLAGH BAHMAN, SHEIKHIAN ALI, JALALI KONDORI BAHMAN. Evaluation of the protective and therapeutic effects of Pistacia atlantica gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(3):248-259. Available from: https://sid.ir/paper/326512/en

    IEEE: Copy

    Zaynab Shakarami, HADI ESMAEILI GOUVARCHIN GHALEH, BAHMAN MANSOURI MOTLAGH, ALI SHEIKHIAN, and BAHMAN JALALI KONDORI, “Evaluation of the protective and therapeutic effects of Pistacia atlantica gum aqueous extract on cellular and pathological aspects of experimental asthma in Balb/c mice,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 3, pp. 248–259, 2019, [Online]. Available: https://sid.ir/paper/326512/en

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