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Information Journal Paper

Title

The neuroprotective mechanism of cinnamaldehyde against amyloid-β in neuronal SHSY5Y cell line: The role of N-methyl-D-aspartate, ryanodine, and adenosine receptors and glycogen synthase kinase-3β

Pages

  271-280

Abstract

 Objective: Cinnamaldehyde may be responsible for some health benefits of cinnamon such as its neuroprotective effects. We aimed to investigate the Cinnamaldehyde neuroprotective effects against amyloid beta (Aβ ) in neuronal SHSY5Y cells and evaluate the contribution of N-methyl-D-aspartate (NMDA), ryanodine, and Adenosine receptors and Glycogen synthase kinase (GSK)-3β , to its neuroprotective effects. Materials and Methods: After seeding the cells in 96-well plates, Adenosine (20, 40, 80, and 120 µ M), NMDA (20, 40, 80, and 120 µ M), and Dantrolene (as a ryanodine receptor antagonist; 2, 4, 6, 8, and 16 µ M) were added to the medium containing Aβ 25-35 and/or Cinnamaldehyde. The 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyl tetrazolium bromide method was used to assess neurotoxicity and western blot to measure the GSK-3β protein level. Results: Cinnamaldehyde (15, 20, 23, and 25 μ M) significantly reversed Aβ-induced toxicity in SHSY5Y neuronal cells. Adenosine (20, 40, 80 and 120 μ M) inhibited the neuroprotective effects of Cinnamaldehyde (15 μ M). NMDA (20, 40, 80, and 120 μ M) reduced Cinnamaldehyde (15 and 23 μ M) neuroprotective effects against Aβ neurotoxicity. Dantrolene (2, 4, 8, and 16 μ M) significantly reduced Cinnamaldehyde (15 μ M) neuroprotective effects. Cinnamaldehyde (15 and 23 μ M) suppressed the Aβ induced increment of GSK-3β protein level. Conclusion: NMDA and Adenosine receptors suppression together with ryanodine receptors stimulation may be relevant to Cinnamaldehyde neuroprotective effects against Aβ neurotoxicity. Moreover, the inhibition of GSK-3β may contribute to the Cinnamaldehyde Neuroprotection.

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    APA: Copy

    EMAMGHOREISHI, MASOUMEH, Farrokhi, Majid Reza, AMIRI, ATENA, & KESHAVARZ, MOJTABA. (2019). The neuroprotective mechanism of cinnamaldehyde against amyloid-β in neuronal SHSY5Y cell line: The role of N-methyl-D-aspartate, ryanodine, and adenosine receptors and glycogen synthase kinase-3β. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(3), 271-280. SID. https://sid.ir/paper/326517/en

    Vancouver: Copy

    EMAMGHOREISHI MASOUMEH, Farrokhi Majid Reza, AMIRI ATENA, KESHAVARZ MOJTABA. The neuroprotective mechanism of cinnamaldehyde against amyloid-β in neuronal SHSY5Y cell line: The role of N-methyl-D-aspartate, ryanodine, and adenosine receptors and glycogen synthase kinase-3β. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(3):271-280. Available from: https://sid.ir/paper/326517/en

    IEEE: Copy

    MASOUMEH EMAMGHOREISHI, Majid Reza Farrokhi, ATENA AMIRI, and MOJTABA KESHAVARZ, “The neuroprotective mechanism of cinnamaldehyde against amyloid-β in neuronal SHSY5Y cell line: The role of N-methyl-D-aspartate, ryanodine, and adenosine receptors and glycogen synthase kinase-3β,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 3, pp. 271–280, 2019, [Online]. Available: https://sid.ir/paper/326517/en

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