Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial

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MOHAMMADPOUR AMIR HOOSHANG; DASTANI MOSTAFA; SALARI ROSHANAK; Radbin Sohrab; MEHRI SOGHRA; GHORBANI MARYAM; Karimani Asieh; SALARI MASOUMEH

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Journal: Avicenna Journal of Phytomedicine Year:2019 | Volume:9 | Issue:5 Page(s): 428-435

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Title

Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial

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Keywords

Curcumin

Interlukein-18

Myeloperoxidase

Matrix metalloproteinase-9

Unstable angina

Abstract

Objective: Inflammation along with oxidative stress plays an important role in the development, progression, instability and rupture of coronary atherosclerotic plaques. Several studies introduced Curcumin (diferuloylmethane) as a wonderful chemical in Curcuma longa (turmeric) with appropriate anti-inflammatory and antioxidant effects. The effect of Curcumin on inflammatory biomarkers was assessed in several clinical trials. This study was designed to evaluate the effect of Curcumin on three pro-inflammatory biomarkers in patients with Unstable angina. Materials and Methods: Forty patients with Unstable angina who met the inclusion criteria, participated in this double-blind randomized clinical trial. Patients were randomly divided into two groups. The patients in the treatment group received nanoCurcumin 80 mg per day for 5 days and the control group received placebo 80 mg per day for five days. Blood samples were obtained before the administration, and also 1, 2 and 4 days after taking the treatment. Serum concentrations of Myeloperoxidase (MPO), Matrix metalloproteinase-9 (MMP-9) and interleukin 18 (IL18) biomarkers were measured by ELISA. Results: There was no significant difference in concentration of these biomarkers before the administration and 1, 2 and 4 days after the start of the trial, between the two groups; however, the concentration of IL-18 on the first day significantly varied between the groups. Conclusion: Based on the findings of this study, administration of nanoCurcumin capsules at the dose of 80 mg per day for 5 days, did not significantly decrease inflammatory biomarkers in patients with Unstable angina.

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APA: Copy

MOHAMMADPOUR, AMIR HOOSHANG, DASTANI, MOSTAFA, SALARI, ROSHANAK, Radbin, Sohrab, MEHRI, SOGHRA, GHORBANI, MARYAM, Karimani, Asieh, & SALARI, MASOUMEH. (2019). Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(5), 428-435. SID. https://sid.ir/paper/326530/en

Vancouver: Copy

MOHAMMADPOUR AMIR HOOSHANG, DASTANI MOSTAFA, SALARI ROSHANAK, Radbin Sohrab, MEHRI SOGHRA, GHORBANI MARYAM, Karimani Asieh, SALARI MASOUMEH. Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(5):428-435. Available from: https://sid.ir/paper/326530/en

IEEE: Copy

AMIR HOOSHANG MOHAMMADPOUR, MOSTAFA DASTANI, ROSHANAK SALARI, Sohrab Radbin, SOGHRA MEHRI, MARYAM GHORBANI, Asieh Karimani, and MASOUMEH SALARI, “Curcumin effects on myeloperoxidase, interleukin-18 and matrix metalloproteinase-9 inflammatory biomarkers in patients with unstable angina: A randomized clinical trial,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 5, pp. 428–435, 2019, [Online]. Available: https://sid.ir/paper/326530/en

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