مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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1

Information Journal Paper

Title

Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial

Pages

  436-445

Abstract

 Objective: Type 2 Diabetes Mellitus (T2DM) is one of the most common health problems worldwide. Studies have shown that Saffron and its derivatives may have therapeutic potentials in T2DM through reducing plasma glucose. The present study aimed to evaluate the effects of Saffron extract on serum anti-Inflammatory and Antioxidant variables in T2DM patients. Materials and Methods: This was a double-blind randomized clinical trial conducted on 64 T2DM patients. Participants received either 15 mg of Saffron or placebo capsules (two pills per day) for 3 months. Anthropometric indices, homocysteine, serum antiInflammatory and Antioxidant variables and dietary intake were assessed pre-and post-intervention. Results: After 3 months of treatment, interleukin-6 (IL-6), and tumor necrosis factor (TNF-α ) increased significantly in both group (p<0. 05). No significant differences were observed for total Antioxidant capacity (TAC), malondialdehyde (MDA), high sensitivity C-reactive protein (hs-CRP) and interleukin 10(IL-10) after the treatment period (p>0. 05). Homocysteine decteased significantly in control group (p<0. 05). Conclusion: Our results showed no improvement in homocystein levels, Antioxidant status and Inflammatory Biomarkers in T2DM patients after treatment with Saffron.

Cites

References

Cite

APA: Copy

SHAHBAZIAN, HAJIEH, MORAVEJ ALEALI, ARMAGHAN, AMANI, REZA, NAMJOOYAN, FOROOGH, CHERAGHIAN, BAHMAN, LATIFI, SEYED MAHMOUD, Bahrainian, Sara, & GHADIRI, ATAALLAH. (2019). Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), 9(5), 436-445. SID. https://sid.ir/paper/326534/en

Vancouver: Copy

SHAHBAZIAN HAJIEH, MORAVEJ ALEALI ARMAGHAN, AMANI REZA, NAMJOOYAN FOROOGH, CHERAGHIAN BAHMAN, LATIFI SEYED MAHMOUD, Bahrainian Sara, GHADIRI ATAALLAH. Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial. AVICENNA JOURNAL OF PHYTOMEDICINE (AJP)[Internet]. 2019;9(5):436-445. Available from: https://sid.ir/paper/326534/en

IEEE: Copy

HAJIEH SHAHBAZIAN, ARMAGHAN MORAVEJ ALEALI, REZA AMANI, FOROOGH NAMJOOYAN, BAHMAN CHERAGHIAN, SEYED MAHMOUD LATIFI, Sara Bahrainian, and ATAALLAH GHADIRI, “Effects of saffron on homocysteine, and antioxidant and inflammatory biomarkers levels in patients with type 2 diabetes mellitus: a randomized double-blind clinical trial,” AVICENNA JOURNAL OF PHYTOMEDICINE (AJP), vol. 9, no. 5, pp. 436–445, 2019, [Online]. Available: https://sid.ir/paper/326534/en

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