EVALUATION OF OXIDATIVE STRESS INDICES IN RAT BRAIN FOLLOWING EXPOSURE TO PARAOXON

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GHANI E.; MOHAMMADI MOSLEM; JAFARI MAHVASH; KHOUSHBATEN A.; ASGARI ALI REZA

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Journal: KOWSAR MEDICAL JOURNAL Year:2008 | Volume:13 | Issue:1 Page(s): 1-7

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Title

EVALUATION OF OXIDATIVE STRESS INDICES IN RAT BRAIN FOLLOWING EXPOSURE TO PARAOXON

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Keywords

PARAOXONQ3

OXIDATIVE STRESSQ2

SUPEROXIDE DISMUTASEQ2

CATALASEQ2

GLUTATHIONEQ3

RATQ3

Abstract

Objective: Evaluation of OXIDATIVE STRESS indices in RAT brain following acute administration of three doses of PARAOXON.Materials and Methods: Male Wistar RATs (200-250 g) were randomly divided into four groupsIncluding: control, and three experimental groups receiving different doses (0.07, 0.35, and 0.7 mg/ kg) of PARAOXON (intraperitoneally). Four hours after injection, brain tissue was quickly removed under ether anesthesia. SUPEROXIDE DISMUTASE (SOD) and CATALASE (CAT) activities, GLUTATHIONE (GSH) and malondialdehyde (MDA) levels were measured.Results: CAT and SOD activities significantly increased at doses 0.35 and 0.7 mg/kg of PARAOXON. Significant reduction in GSH content was observed at 0.7 mg/kg of PARAOXON. MDA concentration showed no significant changes.Conclusion: Present findings indicate that acute exposure to PARAOXON induces free radical production. Increased antioxidant activity and reduced GLUTATHIONE content of brain are indicators of activation of systems protecting the cells by detoxification of free radicals.

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APA: Copy

GHANI, E., MOHAMMADI, MOSLEM, JAFARI, MAHVASH, KHOUSHBATEN, A., & ASGARI, ALI REZA. (2008). EVALUATION OF OXIDATIVE STRESS INDICES IN RAT BRAIN FOLLOWING EXPOSURE TO PARAOXON. KOWSAR MEDICAL JOURNAL, 13(1), 1-7. SID. https://sid.ir/paper/32692/en

Vancouver: Copy

GHANI E., MOHAMMADI MOSLEM, JAFARI MAHVASH, KHOUSHBATEN A., ASGARI ALI REZA. EVALUATION OF OXIDATIVE STRESS INDICES IN RAT BRAIN FOLLOWING EXPOSURE TO PARAOXON. KOWSAR MEDICAL JOURNAL[Internet]. 2008;13(1):1-7. Available from: https://sid.ir/paper/32692/en

IEEE: Copy

E. GHANI, MOSLEM MOHAMMADI, MAHVASH JAFARI, A. KHOUSHBATEN, and ALI REZA ASGARI, “EVALUATION OF OXIDATIVE STRESS INDICES IN RAT BRAIN FOLLOWING EXPOSURE TO PARAOXON,” KOWSAR MEDICAL JOURNAL, vol. 13, no. 1, pp. 1–7, 2008, [Online]. Available: https://sid.ir/paper/32692/en

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