EVALUATION OF THE ROLE OF BASOLATERAL AMYGDALA NUCLEUS IN CORTICOSTERONE EFFECTS ON MEMORY RETRIEVAL IN RAT

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VAFAEI ABAS ALI; RASHIDIPOUR A.; AKHYANI E.; TAHERIAN ABAS ALI; SADEGHI HASAN

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Journal: KOWSAR MEDICAL JOURNAL Year:2007 | Volume:12 | Issue:3 Page(s): 209-217

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Title

EVALUATION OF THE ROLE OF BASOLATERAL AMYGDALA NUCLEUS IN CORTICOSTERONE EFFECTS ON MEMORY RETRIEVAL IN RAT

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Keywords

BASOLATERAL AMYGDALAQ3

CORTICOSTERONEQ3

RATQ3

PASSIVE AVOIDANCE LEARNINGQ3

MEMORY RETRIEVALQ4

Abstract

Introduction: Previous studies have indicated that glucocorticoids receptors (GRs) are involved in leamirrg and memory processes and probably BASOLATERAL AMYGDALA is one of the brain noc1ei that mediates this role. Therefore, this study was aimed to determine the role of BASOLATERAL AMYGDALA (BLA) nucleus in CORTICOSTERONE effects on MEMORY RETRIEVAL in RATs.Material and Methods: In this experimental study, 110 male Wistar RATs (250-300 gr) were used. In experiment l, bilateral cannulae were surgically aimed at BLA and the RATs were trained using PASSIVE AVOIDANCE LEARNING (PAL) task one week later. Retention test was done two days later, during which re-entering into dark chamber (Step-through latency, STL) and time spent in light chamber (TLC) was recorded in a 10 minute test and the results were compared with the control group. 30 minutes before the retrieval test, bilateral intra-BLA injections of CORTICOSTERONE (0.1, 0.5, 1 and 3 /lg for each side) were made. In experiment 2, one week after BLA of the RATs were chemically destroyed by NMDA, they were trained using PAL as mentioned above. Thirty min before the retrieval test which was done 2 days after training; CORTICOSTERONE (1, 3 mg/kg) was injected subcutaneously and results were compared with the sham group. In the end, the possible effects of BLA destruction on their locomotor activity were studied.Results: Data indicated that injection of CORTICOSTERONE into BLA impaired MEMORY RETRIEVAL in a dose- dependent manner (P<0.01). Also, effects of systemic CORTICOSTERONE administration were balanced in the presence of destroyed BLA (P<0.01). BLA destruction did not cause locomotor disorders.Conclusion: Findings show that activation of GRs in BLA plays an important role in retrieval memory and BLA has a critical role in mediating the effects of systemic glucocorticoids on retrieval memory.

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APA: Copy

VAFAEI, ABAS ALI, RASHIDIPOUR, A., AKHYANI, E., TAHERIAN, ABAS ALI, & SADEGHI, HASAN. (2007). EVALUATION OF THE ROLE OF BASOLATERAL AMYGDALA NUCLEUS IN CORTICOSTERONE EFFECTS ON MEMORY RETRIEVAL IN RAT . KOWSAR MEDICAL JOURNAL, 12(3), 209-217. SID. https://sid.ir/paper/32706/en

Vancouver: Copy

VAFAEI ABAS ALI, RASHIDIPOUR A., AKHYANI E., TAHERIAN ABAS ALI, SADEGHI HASAN. EVALUATION OF THE ROLE OF BASOLATERAL AMYGDALA NUCLEUS IN CORTICOSTERONE EFFECTS ON MEMORY RETRIEVAL IN RAT . KOWSAR MEDICAL JOURNAL[Internet]. 2007;12(3):209-217. Available from: https://sid.ir/paper/32706/en

IEEE: Copy

ABAS ALI VAFAEI, A. RASHIDIPOUR, E. AKHYANI, ABAS ALI TAHERIAN, and HASAN SADEGHI, “EVALUATION OF THE ROLE OF BASOLATERAL AMYGDALA NUCLEUS IN CORTICOSTERONE EFFECTS ON MEMORY RETRIEVAL IN RAT ,” KOWSAR MEDICAL JOURNAL, vol. 12, no. 3, pp. 209–217, 2007, [Online]. Available: https://sid.ir/paper/32706/en

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