HALF-SALINE VERSUS COMBINED NORMAL SALINE AND 1/3–2/3 INTRAVENOUS FLUID THERAPY IN KIDNEY TRANSPLANTATION

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GHORBANI A.; FELI M.; EHSANPOUR A.; SHAHBAZIAN H.; HAYATI F.; ROOZBEH J.

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Journal Paper

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Journal: International Journal of Organ Transplantation Medicine Year:2011 | Volume:2 | Issue:3 Page(s): 101-104

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Title

HALF-SALINE VERSUS COMBINED NORMAL SALINE AND 1/3–2/3 INTRAVENOUS FLUID THERAPY IN KIDNEY TRANSPLANTATION

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Keywords

RENAL TRANSPLANTATION

INTRAVENOUS FLUID THERAPY

RENAL FUNCTION

Abstract

Background: Sufficient intravascular volume should be established for optimal graft function after RENAL TRANSPLANTATION. However, there is no recommendation for the type of fluid therapy post-operatively. We compared half-saline vs. normal saline and 1/3–2/3 intravenous fluid replacement after RENAL TRANSPLANTATION.Methods: We enrolled all patients who underwent kidney transplantation between June 2008 and March 2010 in Golestan Hospital, Ahwaz, southwestern Iran. Patients were randomly divided into two groups using a blinded allocation technique. Group A patients (Case) received half saline, and group B patients (Control) received normal saline and 1/3–2/3 intravenous fluid. According to our protocol, we replaced as much as 100% of hourly urine output in the first day, followed by 90% and 70% of every 2-hour urine output in the 2nd and 3rd days, respectively. Blood pressure and pulse rate were recorded hourly. Serum sodium, potassium, creatinine and pH were assessed twice a day.Results: There were 34 and 36 eligible patients in the case and control groups, respectively. The mean±SD 6-hour urine output in the first 5 days after surgery was 2586±725 mL in the control group and 2764±758 mL in the case group (p=0.31). The mean±SD serum creatinine level at the end of the 5th post-operative day was 1.3±0.5 and 1.4±0.7 mg/dL in the case and control groups, respectively (p=0.56). Serum creatinine level did not reduce to 1.5 mg/dL or lower in 6 of 36 control subjects and in 4 of 34 cases at the end of the 5th day (p=0.558). The mean±SD time to creatinine level<1.5 mg/dL was 1.3±1 days in the control group and 1.7±0.8 days in the case group (p=0.635). Hyperkalemia occurred in 3 of 36 patients in the control group and in 2 of 34 patients in the case group (p=0.318). The incidence of hyponatremia in the control group was 11% (4 of 36 patients) vs no patients in the case group (p=0.115).Conclusion: Either half-saline or normal saline and 1/3–2/3 intravenous solution can be safely used as fluid replacement therapy after kidney transplantation.

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APA: Copy

GHORBANI, A., FELI, M., EHSANPOUR, A., SHAHBAZIAN, H., HAYATI, F., & ROOZBEH, J.. (2011). HALF-SALINE VERSUS COMBINED NORMAL SALINE AND 1/3–2/3 INTRAVENOUS FLUID THERAPY IN KIDNEY TRANSPLANTATION. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, 2(3), 101-104. SID. https://sid.ir/paper/327387/en

Vancouver: Copy

GHORBANI A., FELI M., EHSANPOUR A., SHAHBAZIAN H., HAYATI F., ROOZBEH J.. HALF-SALINE VERSUS COMBINED NORMAL SALINE AND 1/3–2/3 INTRAVENOUS FLUID THERAPY IN KIDNEY TRANSPLANTATION. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE[Internet]. 2011;2(3):101-104. Available from: https://sid.ir/paper/327387/en

IEEE: Copy

A. GHORBANI, M. FELI, A. EHSANPOUR, H. SHAHBAZIAN, F. HAYATI, and J. ROOZBEH, “HALF-SALINE VERSUS COMBINED NORMAL SALINE AND 1/3–2/3 INTRAVENOUS FLUID THERAPY IN KIDNEY TRANSPLANTATION,” INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, vol. 2, no. 3, pp. 101–104, 2011, [Online]. Available: https://sid.ir/paper/327387/en

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