LIVER TRANSPLANTATION FOR END-STAGE LIVER DISEASE CAUSED BY AUTOIMMUNE HEPATITIS AND OVERLAP SYNDROM: LONG-TERM FOLLOW-UP

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SHAFIEE M.; KAZEMI K.; NIKEGHBALIAN S.; SHAMSAEEFAR A.R.; BAHADOR A.; SALAHI H.; GHOLAMI S.; MEHRDAD G.; MALEK HOSSEINI S.A.

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Journal: International Journal of Organ Transplantation Medicine Year:2015 | Volume:6 | Issue:3 Page(s): 135-135

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Title

LIVER TRANSPLANTATION FOR END-STAGE LIVER DISEASE CAUSED BY AUTOIMMUNE HEPATITIS AND OVERLAP SYNDROM: LONG-TERM FOLLOW-UP

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Abstract

Background: Liver transplantation is the treatment of choice for end-stage liver disease caused by various etiologies. The three major types of immune liver disease are primary sclerosing cholangitis (PSC), primary biliary cirrhosis (PBC), and autoimmune hepatitis (AIH). Variant types are called "overlap syndrome" but there is no consensus on the definition and diagnosis of this syndrome.Methods: In this study we analyzed post-operative complications (acute and chronic rejection, biliary complication, recurrence after liver transplantation) of patients with autoimmune hepatitis and overlap syndrome who underwent liver transplantation in Shiraz Transplant Center between September 2000 and April 2008. Patients were labeled as overlap syndrome according to Paris criteria.Results: The median follow-up of patients was 105 (range: 82–172) months. Long-term follow-up of 31 patients with AIH and 17 with overlap syndrome, revealed that chronic rejection and biliary complications after liver transplant are significantly more common in patients with overlap syndrome. In this study there was only one case of documented recurrence of AIH post-transplantation.Conclusion: In patients with overlap syndrome, post-operative evaluations should be more intensive to achieve acceptable results in this large group of patients.

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APA: Copy

SHAFIEE, M., KAZEMI, K., NIKEGHBALIAN, S., SHAMSAEEFAR, A.R., BAHADOR, A., SALAHI, H., GHOLAMI, S., MEHRDAD, G., & MALEK HOSSEINI, S.A.. (2015). LIVER TRANSPLANTATION FOR END-STAGE LIVER DISEASE CAUSED BY AUTOIMMUNE HEPATITIS AND OVERLAP SYNDROM: LONG-TERM FOLLOW-UP. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, 6(3), 135-135. SID. https://sid.ir/paper/327531/en

Vancouver: Copy

SHAFIEE M., KAZEMI K., NIKEGHBALIAN S., SHAMSAEEFAR A.R., BAHADOR A., SALAHI H., GHOLAMI S., MEHRDAD G., MALEK HOSSEINI S.A.. LIVER TRANSPLANTATION FOR END-STAGE LIVER DISEASE CAUSED BY AUTOIMMUNE HEPATITIS AND OVERLAP SYNDROM: LONG-TERM FOLLOW-UP. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE[Internet]. 2015;6(3):135-135. Available from: https://sid.ir/paper/327531/en

IEEE: Copy

M. SHAFIEE, K. KAZEMI, S. NIKEGHBALIAN, A.R. SHAMSAEEFAR, A. BAHADOR, H. SALAHI, S. GHOLAMI, G. MEHRDAD, and S.A. MALEK HOSSEINI, “LIVER TRANSPLANTATION FOR END-STAGE LIVER DISEASE CAUSED BY AUTOIMMUNE HEPATITIS AND OVERLAP SYNDROM: LONG-TERM FOLLOW-UP,” INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, vol. 6, no. 3, pp. 135–135, 2015, [Online]. Available: https://sid.ir/paper/327531/en

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