ASSOCIATION OF GSTO2 (N142D) GENETIC POLYMORPHISM AND ACUTE REJECTION OF LIVER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHOSRAVI M.; SAADAT I.; KARIMI M.H.; MALEK HOSSEINI S.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: International Journal of Organ Transplantation Medicine Year:2016 | Volume:7 | Issue:3 Page(s): 183-187

Download Full-Text

View:

271

Download:

126

Cites:

Information Journal Paper

Title

ASSOCIATION OF GSTO2 (N142D) GENETIC POLYMORPHISM AND ACUTE REJECTION OF LIVER

Author(s)

KHOSRAVI M. | SAADAT I. | KARIMI M.H. | MALEK HOSSEINI S.A. | Issue Writer Certificate

Keywords

GRAFT REJECTION

GLUTATHIONE S-TRANSFERASE

POLYMORPHISM

GENETIC

TRANSPLANTATION

METABOLIC DETOXICATION

PHASE II

Abstract

Background: Acute rejection is the main problem in liver TRANSPLANTATION that occurs in the first days or months of TRANSPLANTATION. It includes histological and cellular rejection. Acute histological rejection is confirmed by biopsy. GLUTATHIONE S-TRANSFERASE family is the most important genes in PHASE II detoxification working in xenobiotic and drug metabolism. GSTO2 is one of the members of this family. GSTO2 (N142D) POLYMORPHISM may influence metabolism of immunosuppressive drugs.Objective: To determine if GSTO2 POLYMORPHISM has association with acute liver rejection.Methods: The present study included 120 patients with histological-proven acute liver rejection and 182 patients without acute rejection. Both groups were matched for sex and age. To determine variants of GSTO2, we used polymerase chain reaction-restriction fragment length POLYMORPHISM (PCR-RFLP).Results: There was a significant association between the GSTO2 genotype and acute liver rejection (NN: OR: 3.642, 95% CI: 1.179–5.444) and (ND: OR: 2.533, 95% CI: 1.672–8.149) compared to those with DD geneotype.Conclusion: Recipients with either NN or ND genotype for GSTO2 are more likely to develop acute liver rejection compared to those with DD genotype.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

KHOSRAVI, M., SAADAT, I., KARIMI, M.H., & MALEK HOSSEINI, S.A.. (2016). ASSOCIATION OF GSTO2 (N142D) GENETIC POLYMORPHISM AND ACUTE REJECTION OF LIVER. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, 7(3), 183-187. SID. https://sid.ir/paper/327614/en

Vancouver: Copy

KHOSRAVI M., SAADAT I., KARIMI M.H., MALEK HOSSEINI S.A.. ASSOCIATION OF GSTO2 (N142D) GENETIC POLYMORPHISM AND ACUTE REJECTION OF LIVER. INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE[Internet]. 2016;7(3):183-187. Available from: https://sid.ir/paper/327614/en

IEEE: Copy

M. KHOSRAVI, I. SAADAT, M.H. KARIMI, and S.A. MALEK HOSSEINI, “ASSOCIATION OF GSTO2 (N142D) GENETIC POLYMORPHISM AND ACUTE REJECTION OF LIVER,” INTERNATIONAL JOURNAL OF ORGAN TRANSPLANTATION MEDICINE, vol. 7, no. 3, pp. 183–187, 2016, [Online]. Available: https://sid.ir/paper/327614/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops