CONTRIBUTION OF THE NUCLEUS CUNEIFORMIS TO THE ANTINOCICEPTIVE EFFECTS OF SYSTEMIC MORPHINE ON INFLAMMATORY PAIN IN RATS

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RONAGHI ABDOLAZIZ; EBRAHIMZADEH MOHAMMAD; HAGHPARAST ABBAS

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Journal: Basic and Clinical Neuroscience Year:2011 | Volume:3 | Issue:1 Page(s): 35-43

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Title

CONTRIBUTION OF THE NUCLEUS CUNEIFORMIS TO THE ANTINOCICEPTIVE EFFECTS OF SYSTEMIC MORPHINE ON INFLAMMATORY PAIN IN RATS

Author(s)

RONAGHI ABDOLAZIZ | EBRAHIMZADEH MOHAMMAD | HAGHPARAST ABBAS | Issue Writer Certificate

Keywords

NUCLEUS CUNEIFORMIS

ELECTROLYTIC LESION

REVERSIBLE INACTIVATION

MORPHINE

FORMALIN TEST

RAT

Abstract

Introduction: The role of midbrain reticular formation, which includes the NUCLEUS CUNEIFORMIS (NCF), as a crucial antinociceptive region in descending pain modulation has long been investigated. In this study, we tried to highlight the role of NCF in MORPHINE-induced antinociception in formalin-induced pain model in RATs.Methods: A total of 201 male Wistar RATs weighing 260-310 g were used in this study. The effective dose of MORPHINE in systemic administration (intraperitoneal; i.p.) was determined after a dose- and time-response protocol. In consequent groups, bilateral ELECTROLYTIC LESION (500 mA, 30 sec) or REVERSIBLE INACTIVATION (lidocaine 2%) were used in the NCF before systemic administration of MORPHINE, and then, the nociceptive test was immediately carried out.Results: The results showed that administration of 6 mg/kg MORPHINE, 30 min before the FORMALIN TEST, is the best dose- and time-response set in these experiments. The obtained data also indicated that bilateral electrical destruction or REVERSIBLE INACTIVATION of the NCF significantly decreased antinociceptive responses of systemic MORPHINE (6 mg/kg; i.p.) during the second phase of FORMALIN TEST (P<0.05).Discussion: Therefore, it seems that opioid receptors located in the NCF may be involved in modulation of central sensitization which occurred in inflammatory pain in RATs.

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APA: Copy

RONAGHI, ABDOLAZIZ, EBRAHIMZADEH, MOHAMMAD, & HAGHPARAST, ABBAS. (2011). CONTRIBUTION OF THE NUCLEUS CUNEIFORMIS TO THE ANTINOCICEPTIVE EFFECTS OF SYSTEMIC MORPHINE ON INFLAMMATORY PAIN IN RATS. BASIC AND CLINICAL NEUROSCIENCE, 3(1), 35-43. SID. https://sid.ir/paper/327657/en

Vancouver: Copy

RONAGHI ABDOLAZIZ, EBRAHIMZADEH MOHAMMAD, HAGHPARAST ABBAS. CONTRIBUTION OF THE NUCLEUS CUNEIFORMIS TO THE ANTINOCICEPTIVE EFFECTS OF SYSTEMIC MORPHINE ON INFLAMMATORY PAIN IN RATS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2011;3(1):35-43. Available from: https://sid.ir/paper/327657/en

IEEE: Copy

ABDOLAZIZ RONAGHI, MOHAMMAD EBRAHIMZADEH, and ABBAS HAGHPARAST, “CONTRIBUTION OF THE NUCLEUS CUNEIFORMIS TO THE ANTINOCICEPTIVE EFFECTS OF SYSTEMIC MORPHINE ON INFLAMMATORY PAIN IN RATS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 3, no. 1, pp. 35–43, 2011, [Online]. Available: https://sid.ir/paper/327657/en

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