مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

PROTECTIVE EFFECTS OF N-ACETYL-L-CYSTEIN ON 3, 4-METHYLENE DIOXYMETHAMPHETAMIE-INDUCED NEUROTOXICITY IN CEREBELLUM OF MALE RATS

Pages

  44-47

Abstract

 Introduction: 3-4, methylenedioxymethamphetamine (MDMA) causes APOPTOSIS in nervous system and several studies suggest that oxidative stress contributes to MDMA-induced neurotoxicity. The aim of this study is to examine the effects of N-acetyl-L-Cystein (NAC) as an antioxidant on MDMA-induced APOPTOSIS.Methods: 21 Sprague dawley male rats (200-250mg) were treated with MDMA (2×0, 5mg/kg) or MDMA plus NAC (100mg/kg IP for 7 day). After last administration of MDMA, rats were killed, cerebellum was removed and Bax and Bcl-2 expression was assessed by western blotting method.Results: The results of this study showed that MDMA causes up-regulation of Bax and down-regulation of Bcl-2 and NAC administration attenuated MDMA-induced APOPTOSIS.Discussion: The present study suggests that NAC treatment may improve MDMA-induced neurotoxicity.

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    APA: Copy

    SOLEIMANI ASL, SARA, FALAHATI, PEIMAN, SHEKARRIZ, NIMA, MOLAVI, NIMA, ESMAEILI, FARZANEH, AZIMI, ZAHRA, SAJADI, FREIDOON, HAYAT, PARISA, SAMZADEH KERMANI, ALIREZA, & MEHDIZADEH, MEHDI. (2011). PROTECTIVE EFFECTS OF N-ACETYL-L-CYSTEIN ON 3, 4-METHYLENE DIOXYMETHAMPHETAMIE-INDUCED NEUROTOXICITY IN CEREBELLUM OF MALE RATS. BASIC AND CLINICAL NEUROSCIENCE, 3(1), 44-47. SID. https://sid.ir/paper/327658/en

    Vancouver: Copy

    SOLEIMANI ASL SARA, FALAHATI PEIMAN, SHEKARRIZ NIMA, MOLAVI NIMA, ESMAEILI FARZANEH, AZIMI ZAHRA, SAJADI FREIDOON, HAYAT PARISA, SAMZADEH KERMANI ALIREZA, MEHDIZADEH MEHDI. PROTECTIVE EFFECTS OF N-ACETYL-L-CYSTEIN ON 3, 4-METHYLENE DIOXYMETHAMPHETAMIE-INDUCED NEUROTOXICITY IN CEREBELLUM OF MALE RATS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2011;3(1):44-47. Available from: https://sid.ir/paper/327658/en

    IEEE: Copy

    SARA SOLEIMANI ASL, PEIMAN FALAHATI, NIMA SHEKARRIZ, NIMA MOLAVI, FARZANEH ESMAEILI, ZAHRA AZIMI, FREIDOON SAJADI, PARISA HAYAT, ALIREZA SAMZADEH KERMANI, and MEHDI MEHDIZADEH, “PROTECTIVE EFFECTS OF N-ACETYL-L-CYSTEIN ON 3, 4-METHYLENE DIOXYMETHAMPHETAMIE-INDUCED NEUROTOXICITY IN CEREBELLUM OF MALE RATS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 3, no. 1, pp. 44–47, 2011, [Online]. Available: https://sid.ir/paper/327658/en

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    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
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