VARENICLINE AMELIORATES LEARNING AND MEMORY DEFICITS IN AMYLOID β (25–35) RAT MODEL OF ALZHEIMER’S DISEASE

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BALUCHNEJADMOJARAD TOURANDOKHT; ROGHANI MEHRDAD; KARIMI NARGES; KAMRAN MITRA

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Journal: Basic and Clinical Neuroscience Year:2011 | Volume:3 | Issue:1 Page(s): 48-57

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Title

VARENICLINE AMELIORATES LEARNING AND MEMORY DEFICITS IN AMYLOID β (25–35) RAT MODEL OF ALZHEIMER’S DISEASE

Author(s)

BALUCHNEJADMOJARAD TOURANDOKHT | ROGHANI MEHRDAD | KARIMI NARGES | KAMRAN MITRA | Issue Writer Certificate

Keywords

Aβ (25–35)

VARENICLINE

PASSIVE AVOIDANCE

Y MAZE

RADIAL MAZE

RAT

Abstract

Introduction: Alzheimer’s disease (AD) is a enfeeble neurodegenerative disorder characterized by increased b-amyloid (Ab) deposition and neuronal dysfunction leading to impaired learning and recall. Among proposed risk factors, impaired cholinergic transmission is a main cause for incidence of disease.Methods: In the present study, effects of the intracerebroventricularly administration of an agonist of nicotinic cholinergic receptors, VARENICLINE (0.5 and 2 mg/ml), on learning and memory impairments induced by intrahippocampal Ab (25–35) injection was assessed in RATs.Results: The results showed that the intrahippocampal Ab (25–35) injected RATs exhibit lower spontaneous alternation score inY-maze tasks (p<0.05), impaired retention and recall capability in the PASSIVE AVOIDANCE test (p<0.05), and fewer correct choices (p<0.001) and more errors (p<0.001) in the RAM task. VARENICLINE, almost in both doses, significantly improved alternation score in Y-maze task (p<0.001), impaired retention and recall capability in the PASSIVE AVOIDANCE test (p<0.05), and correct choices in the RAM task (p<0.001).Discussion: This study indicates that VARENICLINE pretreatment attenuates Ab-induced impairment of short-term spatial memory in RATs probably due to its agonist activity at nicotinic receptors.

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APA: Copy

BALUCHNEJADMOJARAD, TOURANDOKHT, ROGHANI, MEHRDAD, KARIMI, NARGES, & KAMRAN, MITRA. (2011). VARENICLINE AMELIORATES LEARNING AND MEMORY DEFICITS IN AMYLOID β (25–35) RAT MODEL OF ALZHEIMER’S DISEASE. BASIC AND CLINICAL NEUROSCIENCE, 3(1), 48-57. SID. https://sid.ir/paper/327660/en

Vancouver: Copy

BALUCHNEJADMOJARAD TOURANDOKHT, ROGHANI MEHRDAD, KARIMI NARGES, KAMRAN MITRA. VARENICLINE AMELIORATES LEARNING AND MEMORY DEFICITS IN AMYLOID β (25–35) RAT MODEL OF ALZHEIMER’S DISEASE. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2011;3(1):48-57. Available from: https://sid.ir/paper/327660/en

IEEE: Copy

TOURANDOKHT BALUCHNEJADMOJARAD, MEHRDAD ROGHANI, NARGES KARIMI, and MITRA KAMRAN, “VARENICLINE AMELIORATES LEARNING AND MEMORY DEFICITS IN AMYLOID β (25–35) RAT MODEL OF ALZHEIMER’S DISEASE,” BASIC AND CLINICAL NEUROSCIENCE, vol. 3, no. 1, pp. 48–57, 2011, [Online]. Available: https://sid.ir/paper/327660/en

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