EFFECTS OF HYDROALCOHOLIC EXTRACT OF TANACETUM SONBOLII (ASTERACEAE) ON PAIN-RELATED BEHAVIORS DURING FORMALIN TEST IN MICE

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SOFIABADI MOHAMMAD; AZHDARI ZARMEHRI HASSAN; NADERI FIROUZEH; GHALANDARI SHAMAMI MOHADESEH; SONBOLI ALI; HAGHPARAST ABBAS

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Journal: Basic and Clinical Neuroscience Year:2014 | Volume:5 | Issue:2 Page(s): 162-168

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Title

EFFECTS OF HYDROALCOHOLIC EXTRACT OF TANACETUM SONBOLII (ASTERACEAE) ON PAIN-RELATED BEHAVIORS DURING FORMALIN TEST IN MICE

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Keywords

TANACETUM SONBOLII (ASTERACEAE)

MORPHINE

FORMALIN TEST

MICE

Abstract

Introduction: Tanacetum sonbolii (Asteraceae) is an endemic species in Iran. In the present study, we examined the effects of Tanacetum sonbolii hydroalcoholic extract on the FORMALIN TEST in MICE.Methods: 126 Swiss albino MICE weighing 230-280g were used as subjects. The FORMALIN TEST was performed on two control groups (marked as intact and saline groups; n=6 in each group) and an experimental group. In all groups, the FORMALIN TEST was recorded for 60 min after administration of extract and drugs in MICE.Results: The results showed that Tanacetum sonbolii (150 and 300 mg/kg) produced significant antinociception in phase 2. In addition, different doses of Tanacetum sonbolii extract (600, 900 and 1200 mg/kg) also induced antinociceptive effects in phase1 and phase 2. On the other hand, MORPHINE could induce antinociception in a dose-dependent manner. Diclofenac (10 mg/ kg) failed to affect the pain scores compared to Tanacetum sonbolii (300 mg/kg) group.Discussion: It seems that administration of hydroalcoholic extract of Tanacetum sonbolii has the potential to relieve pain through both central and peripheral mechanisms in persistent inflammatory nociception.

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APA: Copy

SOFIABADI, MOHAMMAD, AZHDARI ZARMEHRI, HASSAN, NADERI, FIROUZEH, GHALANDARI SHAMAMI, MOHADESEH, SONBOLI, ALI, & HAGHPARAST, ABBAS. (2014). EFFECTS OF HYDROALCOHOLIC EXTRACT OF TANACETUM SONBOLII (ASTERACEAE) ON PAIN-RELATED BEHAVIORS DURING FORMALIN TEST IN MICE. BASIC AND CLINICAL NEUROSCIENCE, 5(2), 162-168. SID. https://sid.ir/paper/327680/en

Vancouver: Copy

SOFIABADI MOHAMMAD, AZHDARI ZARMEHRI HASSAN, NADERI FIROUZEH, GHALANDARI SHAMAMI MOHADESEH, SONBOLI ALI, HAGHPARAST ABBAS. EFFECTS OF HYDROALCOHOLIC EXTRACT OF TANACETUM SONBOLII (ASTERACEAE) ON PAIN-RELATED BEHAVIORS DURING FORMALIN TEST IN MICE. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2014;5(2):162-168. Available from: https://sid.ir/paper/327680/en

IEEE: Copy

MOHAMMAD SOFIABADI, HASSAN AZHDARI ZARMEHRI, FIROUZEH NADERI, MOHADESEH GHALANDARI SHAMAMI, ALI SONBOLI, and ABBAS HAGHPARAST, “EFFECTS OF HYDROALCOHOLIC EXTRACT OF TANACETUM SONBOLII (ASTERACEAE) ON PAIN-RELATED BEHAVIORS DURING FORMALIN TEST IN MICE,” BASIC AND CLINICAL NEUROSCIENCE, vol. 5, no. 2, pp. 162–168, 2014, [Online]. Available: https://sid.ir/paper/327680/en

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