MICROINFUSION OF BUPROPION INHIBITS PUTATIVE GABAERGIC NEURONAL ACTIVITY OF THE VENTRAL TEGMENTAL AREA

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AMIRABADI SANAZ; GHADERI PAKDEL FIROUZ; SHAHABI PARVIZ; NADERI SOMAYYEH; ASHRAFI OSALOU MOSTAFA; CANKURT ULKER

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Journal: Basic and Clinical Neuroscience Year:2014 | Volume:5 | Issue:3 Page(s): 182-190

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Title

MICROINFUSION OF BUPROPION INHIBITS PUTATIVE GABAERGIC NEURONAL ACTIVITY OF THE VENTRAL TEGMENTAL AREA

Author(s)

Keywords

BUPROPION

ANTIDEPRESSANT

VENTRAL TEGMENTAL AREA

RAT

PUTATIVE GABAERGIC

NON-DOPAMINERGIC

Abstract

Introduction: The most common interpretation for the mechanisms of antidepression is the increase of the brain monoamine levels such as dopamine (DA). The increase of DA can reduce depression but it can also decrease the monoamine release because of autoreceptor inhibition.Although BUPROPION can decrease the dopamine release, there is evidence about stimulatory effects of chronic application of BUPROPION on VENTRAL TEGMENTAL AREA (VTA) neurons. In this study, the intra-VTA acute microinfusion of BUPROPION on putative VTA NON-DOPAMINERGIC (VTA-nonDA) neuronal firing RATes was evaluated by a single neuron recording technique.Methods: Animals were divided into 7 groups (sham, and 6 BUPROPION-microinfused groups with 1, 10-1, 10-2, 10-3, 10-4, and 10-5 mol, 1 ml/3 min, intra-VTA). A single neuron recording technique was done according to the stereotaxic coordination. After 10 min baseline recording, ACSF or BUPROPION was microinfused. The recording continued to recovery period in the treated groups. The prestimulus time (PST) and interspike interval (ISI) histograms were calculated for every single unit. The assessment of the drug effect was carried out by one-way analysis of variance (ANOVA) and Post-hoc test.Results: 126 non-DA neurons were separated. BUPROPION could inhibit 116 neurons and 11 neurons had no significant response. Maximum inhibition was 79.1% of baseline firing RATe with 44.3 min duration. The inhibitory effect of BUPROPION was dose-dependent.Discussion: The acute inhibitory effects of BUPROPION on VTA-nonDA neurons can explain the fast inhibitory effects of BUPROPION and other ANTIDEPRESSANTs on the VTA. These data can explain some side effects of ANTIDEPRESSANTs.

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APA: Copy

AMIRABADI, SANAZ, GHADERI PAKDEL, FIROUZ, SHAHABI, PARVIZ, NADERI, SOMAYYEH, ASHRAFI OSALOU, MOSTAFA, & CANKURT, ULKER. (2014). MICROINFUSION OF BUPROPION INHIBITS PUTATIVE GABAERGIC NEURONAL ACTIVITY OF THE VENTRAL TEGMENTAL AREA. BASIC AND CLINICAL NEUROSCIENCE, 5(3), 182-190. SID. https://sid.ir/paper/327733/en

Vancouver: Copy

AMIRABADI SANAZ, GHADERI PAKDEL FIROUZ, SHAHABI PARVIZ, NADERI SOMAYYEH, ASHRAFI OSALOU MOSTAFA, CANKURT ULKER. MICROINFUSION OF BUPROPION INHIBITS PUTATIVE GABAERGIC NEURONAL ACTIVITY OF THE VENTRAL TEGMENTAL AREA. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2014;5(3):182-190. Available from: https://sid.ir/paper/327733/en

IEEE: Copy

SANAZ AMIRABADI, FIROUZ GHADERI PAKDEL, PARVIZ SHAHABI, SOMAYYEH NADERI, MOSTAFA ASHRAFI OSALOU, and ULKER CANKURT, “MICROINFUSION OF BUPROPION INHIBITS PUTATIVE GABAERGIC NEURONAL ACTIVITY OF THE VENTRAL TEGMENTAL AREA,” BASIC AND CLINICAL NEUROSCIENCE, vol. 5, no. 3, pp. 182–190, 2014, [Online]. Available: https://sid.ir/paper/327733/en

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