ANXIOLYTIC-LIKE EFFECTS AND INCREASE IN LOCOMOTOR ACTIVITY INDUCED BY INFUSIONS OF NMDA INTO THE VENTRAL HIPPOCAMPUS IN RAT: INTERACTION WITH GABAERGIC SYSTEM

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BINA PAYVAND; REZVANFARD MEHRNAZ; AHMADI SHAMSEDDIN; ZARRINDAST MOHAMMAD REZA

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Journal: Basic and Clinical Neuroscience Year:2014 | Volume:5 | Issue:4 Page(s): 267-276

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Title

ANXIOLYTIC-LIKE EFFECTS AND INCREASE IN LOCOMOTOR ACTIVITY INDUCED BY INFUSIONS OF NMDA INTO THE VENTRAL HIPPOCAMPUS IN RAT: INTERACTION WITH GABAERGIC SYSTEM

Author(s)

BINA PAYVAND | REZVANFARD MEHRNAZ | AHMADI SHAMSEDDIN | ZARRINDAST MOHAMMAD REZA | Issue Writer Certificate

Keywords

ANXIETY-LIKE BEHAVIOR

ELEVATED-PLUS MAZE

NMDA

MUSCIMOL

BICUCULLINE

Abstract

Introduction: In this study, we investigated the role of N-Methyl-D-Aspartate (NMDA) receptors in the ventral hippocampus (VH) and their possible interactions with GABAA system on ANXIETY-LIKE BEHAVIORs.Methods: We used an ELEVATED-PLUS MAZE test (EPM) to assess ANXIETY-LIKE BEHAVIORs and locomotor activity in male Wistar rats.Results: The results showed that intra-VH infusions of different doses of NMDA (0.25 and 0.5 mg/rat) increased locomotor activity, and also induced anxiolytic-like behaviors, as revealed by a tendency to increase percentage of open arm time (%OAT), and a significant increase in percentage of open arm entries (%OAE). The results also showed that intra-VH infusions of MUSCIMOL (0.5 and 1 mg/rat) or BICUCULLINE (0.5 and 1 mg/rat) did not significantly affect ANXIETY-LIKE BEHAVIORs, but BICUCULLINE at dose of 1 mg/rat increased locomotor activity. Intra- VH co-infusions of MUSCIMOL (0.5 mg/rat) along with low doses of NMDA (0.0625 and 0.125 mg/rat) showed a tendency to increase %OAT, %OAE and locomotor activity; however, no interaction was observed between the drugs. Interestingly, intra-VH co-infusions of BICUCULLINE (0.5 mg/rat) along with effective doses of NMDA (0.25 and 0.5 mg/rat) decreased %OAT, %OAE and locomotor activity, and a significant interaction between two drugs was observed.Discussion: It can be concluded that GABAergic system may mediate the anxiolytic-like effects and increase in locomotor activity induced by NMDA in the VH.

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APA: Copy

BINA, PAYVAND, REZVANFARD, MEHRNAZ, AHMADI, SHAMSEDDIN, & ZARRINDAST, MOHAMMAD REZA. (2014). ANXIOLYTIC-LIKE EFFECTS AND INCREASE IN LOCOMOTOR ACTIVITY INDUCED BY INFUSIONS OF NMDA INTO THE VENTRAL HIPPOCAMPUS IN RAT: INTERACTION WITH GABAERGIC SYSTEM. BASIC AND CLINICAL NEUROSCIENCE, 5(4), 267-276. SID. https://sid.ir/paper/327789/en

Vancouver: Copy

BINA PAYVAND, REZVANFARD MEHRNAZ, AHMADI SHAMSEDDIN, ZARRINDAST MOHAMMAD REZA. ANXIOLYTIC-LIKE EFFECTS AND INCREASE IN LOCOMOTOR ACTIVITY INDUCED BY INFUSIONS OF NMDA INTO THE VENTRAL HIPPOCAMPUS IN RAT: INTERACTION WITH GABAERGIC SYSTEM. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2014;5(4):267-276. Available from: https://sid.ir/paper/327789/en

IEEE: Copy

PAYVAND BINA, MEHRNAZ REZVANFARD, SHAMSEDDIN AHMADI, and MOHAMMAD REZA ZARRINDAST, “ANXIOLYTIC-LIKE EFFECTS AND INCREASE IN LOCOMOTOR ACTIVITY INDUCED BY INFUSIONS OF NMDA INTO THE VENTRAL HIPPOCAMPUS IN RAT: INTERACTION WITH GABAERGIC SYSTEM,” BASIC AND CLINICAL NEUROSCIENCE, vol. 5, no. 4, pp. 267–276, 2014, [Online]. Available: https://sid.ir/paper/327789/en

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