ELEVATED IL-17 AND TGF-β SERUM LEVELS: A POSITIVE CORRELATION BETWEEN T-HELPER 17 CELL-RELATED PRO-INFLAMMATORY RESPONSES WITH MAJOR DEPRESSIVE DISORDER

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DAVAMI MOHAMMAD HASAN; BAHARLOU RASOUL; AHMADI VASMEHJANI ABBAS; GHANIZADEH AHMAD; KESHTKAR MITRA; DEZHKAM IMAN; ATASHZAR MOHAMMAD REZA

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Journal: Basic and Clinical Neuroscience Year:2016 | Volume:7 | Issue:2 Page(s): 137-142

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Title

ELEVATED IL-17 AND TGF-β SERUM LEVELS: A POSITIVE CORRELATION BETWEEN T-HELPER 17 CELL-RELATED PRO-INFLAMMATORY RESPONSES WITH MAJOR DEPRESSIVE DISORDER

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Keywords

MAJOR DEPRESSIVE DISORDER

INTERLEUKIN-17

INTERLEUKIN-21

TRANSFORMING GROWTH FACTOR-BETA

INFLAMMATORY RESPONSE

Abstract

Introduction: Depression is a mental disorder that highly associated with immune system.Therefore, this study compares the serum concentrations of IL-21, IL-17, and transforming growth factor b (TGF- b) between patients with MAJOR DEPRESSIVE DISORDER and healthy controls.Methods: Blood samples were collected from 41 patients with MAJOR DEPRESSIVE DISORDER and 40 healthy age-matched controls with no history of malignancies or autoimmune disorders. The subjects were interviewed face to face according to DSM-IV diagnostic criteria. Depression score was measured using completed Beck Depression Inventory in both groups. The serum concentrations of IL-21, IL-17, and TGF-β were assessed using ELISA.Results: The mean score of Beck Depression score in the patient and control groups was 35.4±5.5 and 11.1±2.3. IL-17 serum concentrations in the patients and the control group were 10.03±0.6 and 7.6±0.6 pg/mL, respectively (P=0.0002). TGF-β level in the patients group was significantly higher than compare to the control group; 336.7±20.19 vs.174.8±27.20 pg/mL, (P<0.0001). However, the level of IL-21 was not statistically different between the two groups 84.30±4.57 vs.84.12±4.15 pg/mL (P>0.05).Conclusion: Considering pro-inflammatory cytokines, current results support the association of INFLAMMATORY RESPONSE and depressive disorder. So, it seems that pro-inflammatory factors profile can be used as indicator in following of depression progress and its treatment impacts.

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APA: Copy

DAVAMI, MOHAMMAD HASAN, BAHARLOU, RASOUL, AHMADI VASMEHJANI, ABBAS, GHANIZADEH, AHMAD, KESHTKAR, MITRA, DEZHKAM, IMAN, & ATASHZAR, MOHAMMAD REZA. (2016). ELEVATED IL-17 AND TGF-β SERUM LEVELS: A POSITIVE CORRELATION BETWEEN T-HELPER 17 CELL-RELATED PRO-INFLAMMATORY RESPONSES WITH MAJOR DEPRESSIVE DISORDER. BASIC AND CLINICAL NEUROSCIENCE, 7(2), 137-142. SID. https://sid.ir/paper/327804/en

Vancouver: Copy

DAVAMI MOHAMMAD HASAN, BAHARLOU RASOUL, AHMADI VASMEHJANI ABBAS, GHANIZADEH AHMAD, KESHTKAR MITRA, DEZHKAM IMAN, ATASHZAR MOHAMMAD REZA. ELEVATED IL-17 AND TGF-β SERUM LEVELS: A POSITIVE CORRELATION BETWEEN T-HELPER 17 CELL-RELATED PRO-INFLAMMATORY RESPONSES WITH MAJOR DEPRESSIVE DISORDER. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2016;7(2):137-142. Available from: https://sid.ir/paper/327804/en

IEEE: Copy

MOHAMMAD HASAN DAVAMI, RASOUL BAHARLOU, ABBAS AHMADI VASMEHJANI, AHMAD GHANIZADEH, MITRA KESHTKAR, IMAN DEZHKAM, and MOHAMMAD REZA ATASHZAR, “ELEVATED IL-17 AND TGF-β SERUM LEVELS: A POSITIVE CORRELATION BETWEEN T-HELPER 17 CELL-RELATED PRO-INFLAMMATORY RESPONSES WITH MAJOR DEPRESSIVE DISORDER,” BASIC AND CLINICAL NEUROSCIENCE, vol. 7, no. 2, pp. 137–142, 2016, [Online]. Available: https://sid.ir/paper/327804/en

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