مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

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Information Journal Paper

Title

EFFECT OF GALLIC ACID ON DEMENTIA TYPE OF ALZHEIMER DISEASE IN RATS: ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDIES

Pages

  97-106

Abstract

 Introduction: To study the effect of gallic acid (GA) on hippocampal LONG-TERM POTENTIATION (LTP) and histological changes in animal model of ALZHEIMER DISEASE (AD) induced by BETA-AMYLOID (Ab).Methods: Sixty-four adult male Wistar RATs (300±20 g) were divided into 8 groups: 1) Control (Cont); 2) AD; 3) Sham; 4-7) AD+GA (50, 100, and 200 mg/kg for 10 days, orally) or vehicle, 8) Cont+GA100, Ab (1μg/mL in each site) was infused into hippocampus bilaterally. Changes of amplitude and slope of LTP induced in hippocampal dentate gyrus (DG) were evaluated by high frequency stimulation (HFS) of perforant path (PP).Results: Data showed that LTP amplitude and area under curve significantly impaired in AD RATs (P<0.001), while significantly improved in AD RATs treated with GA (P<0.05, P<0.01).Conclusion: Current findings suggest that GA reduces neural damage and brain amyloid neuropathology and improves cognitive function via free radicals scavenging and inhibiting oligomerization of Ab but with no effect on healthy RATs.

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    APA: Copy

    HAJIPOUR, SOMAYEH, SARKAKI, ALIREZA, FARBOOD, YAGHOOB, EIDI, AKRAM, MORTAZAVI, PEJMAN, & VALIZADEH, ZOHREH. (2016). EFFECT OF GALLIC ACID ON DEMENTIA TYPE OF ALZHEIMER DISEASE IN RATS: ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDIES. BASIC AND CLINICAL NEUROSCIENCE, 7(2), 97-106. SID. https://sid.ir/paper/327810/en

    Vancouver: Copy

    HAJIPOUR SOMAYEH, SARKAKI ALIREZA, FARBOOD YAGHOOB, EIDI AKRAM, MORTAZAVI PEJMAN, VALIZADEH ZOHREH. EFFECT OF GALLIC ACID ON DEMENTIA TYPE OF ALZHEIMER DISEASE IN RATS: ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDIES. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2016;7(2):97-106. Available from: https://sid.ir/paper/327810/en

    IEEE: Copy

    SOMAYEH HAJIPOUR, ALIREZA SARKAKI, YAGHOOB FARBOOD, AKRAM EIDI, PEJMAN MORTAZAVI, and ZOHREH VALIZADEH, “EFFECT OF GALLIC ACID ON DEMENTIA TYPE OF ALZHEIMER DISEASE IN RATS: ELECTROPHYSIOLOGICAL AND HISTOLOGICAL STUDIES,” BASIC AND CLINICAL NEUROSCIENCE, vol. 7, no. 2, pp. 97–106, 2016, [Online]. Available: https://sid.ir/paper/327810/en

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