ANALGESIC EFFECT OF 17Β-ESTRADIOL ON NUCLEUS PARAGIGANTOCELLULARIS LATERALIS OF MALE RATS MEDIATED VIA GABAA RECEPTORS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHAKPAY ROGHAIEH; AZADDAR MARYAM; KHAKPAY FATEMEH; HATAMI NEMATI HOMEIRA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Basic and Clinical Neuroscience Year:2017 | Volume:8 | Issue:1 Page(s): 51-59

Download Full-Text

View:

229

Download:

239

Cites:

Information Journal Paper

Title

ANALGESIC EFFECT OF 17Β-ESTRADIOL ON NUCLEUS PARAGIGANTOCELLULARIS LATERALIS OF MALE RATS MEDIATED VIA GABAA RECEPTORS

Author(s)

KHAKPAY ROGHAIEH | AZADDAR MARYAM | KHAKPAY FATEMEH | HATAMI NEMATI HOMEIRA | Issue Writer Certificate

Keywords

17β-ESTRADIOL

GABAA RECEPTOR

PAIN

ANALGESIA

Abstract

Introduction: Beside its autonomic functions, the nucleus paragigantocellularis lateralis (LPGi) is involved in the descending PAIN modulation.17b-Estradiol is a neuroactive steroid found in several brain areas such as LPGi. Intra-LPGi microinjection of 17b-estradiol can elicit the analgesic responses.17b-Estradiol modulates nociception by binding to estrogenic receptors as well as allosteric interaction with other membrane-bound receptors like GABAA receptors. This study aimed to examine the role of GABAA receptors in the PAIN modulating effect of intra-LPGi injection of 17b-estradiol.Methods: To study the antinociceptive effects of 17b-estradiol, cannulation into the LPGi nucleus of male Wistar rats was performed. About 500 nL of drug was administered 15 minutes prior to formalin injection (50 mL of 4%). Then, formalin-induced flexing and licking behaviors were recorded for 60 minutes. For evaluating the role of GABAA receptors in the estradiol-induced PAIN modulation, 17b-estradiol was administered into the LPGi nucleus 15 minutes after the injection of 25 ng/mL bicuculline (the GABAA receptor antagonist). Then, the formalin-induced responses were recorded.Results: The results of the current study showed that intra-LPGi injection of 17b-estradiol decreased the flexing duration in both phases of formalin test (P<0.001); but it only attenuated the second phase of licking behavior (P<0.001).17b-estradiol attenuated the second phase of formalin test of both behaviors (P<0.001). Bicuculline prevented the antinociceptive effect of intra-LPGi 17b-estradiol in both first and second phases of formalin-induced responses (P<0.001).Conclusion: According to the results of this study, the analgesic effect of intra-LPGi 17b-estradiol on the formalin-induced inflammatory PAIN might be mediated via GABAA receptors.

Cites

ROLE OF THE AMPA RECEPTORS OF PARAGIGANTOCELLULARIS LATERALIS NUCLEUS IN THE INFLAMMATORY PAIN MODULATION IN MALE RAT

References

No record.

Cite

APA: Copy

KHAKPAY, ROGHAIEH, AZADDAR, MARYAM, KHAKPAY, FATEMEH, & HATAMI NEMATI, HOMEIRA. (2017). ANALGESIC EFFECT OF 17?-ESTRADIOL ON NUCLEUS PARAGIGANTOCELLULARIS LATERALIS OF MALE RATS MEDIATED VIA GABA_A RECEPTORS. BASIC AND CLINICAL NEUROSCIENCE, 8(1), 51-59. SID. https://sid.ir/paper/327829/en

Vancouver: Copy

KHAKPAY ROGHAIEH, AZADDAR MARYAM, KHAKPAY FATEMEH, HATAMI NEMATI HOMEIRA. ANALGESIC EFFECT OF 17?-ESTRADIOL ON NUCLEUS PARAGIGANTOCELLULARIS LATERALIS OF MALE RATS MEDIATED VIA GABA_A RECEPTORS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2017;8(1):51-59. Available from: https://sid.ir/paper/327829/en

IEEE: Copy

ROGHAIEH KHAKPAY, MARYAM AZADDAR, FATEMEH KHAKPAY, and HOMEIRA HATAMI NEMATI, “ANALGESIC EFFECT OF 17?-ESTRADIOL ON NUCLEUS PARAGIGANTOCELLULARIS LATERALIS OF MALE RATS MEDIATED VIA GABA_A RECEPTORS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 8, no. 1, pp. 51–59, 2017, [Online]. Available: https://sid.ir/paper/327829/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops