PROTECTIVE EFFECTS OF CYPERUS ROTUNDUS EXTRACT ON AMYLOID β-PEPTIDE (1-40)-INDUCED MEMORY IMPAIRMENT IN MALE RATS: A BEHAVIORAL STUDY

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MEHDIZADEH MEHDI; HASHEM DABAGHIAN FATANEH; shojaee Asie; MOLAVI NIMA; TASLIMI ZAHRA; SHABANI RONAK; SOLEIMANI ASL SARA

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Journal: Basic and Clinical Neuroscience Year:2017 | Volume:8 | Issue:3 Page(s): 249-254

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Title

PROTECTIVE EFFECTS OF CYPERUS ROTUNDUS EXTRACT ON AMYLOID β-PEPTIDE (1-40)-INDUCED MEMORY IMPAIRMENT IN MALE RATS: A BEHAVIORAL STUDY

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Keywords

ALZHEIMER DISEASE

AMYLOID β-PEPTIDE

CYPERUS ROTUNDUS

SPATIAL MEMORY

Abstract

Introduction: The ALZHEIMER DISEASE (AD) is the most common form of dementia that leads to memory impairment. As the oxidative stress plays an important role in AD pathogenesis, the current study aimed at examining the protective effects of CYPERUS ROTUNDUS as an antioxidant on amyloid b (Ab) -induced memory impairment.Methods: Twenty-eight Wistar male rats received intrahippocampal (IHP) injection of the Ab (1- 40) and C. rotundus (400 mg/kg, intraperitoneally). SPATIAL MEMORY was assessed by the Morris water-maze (MWM) task.Results: In the MWM, Ab (1-40) significantly increased escape latency and traveled distance (P<0.001). The administration of C. rotundus attenuated the Ab-induced memory impairment in the MWM task.Conclusion: The current study findings showed that C. Rotundus could improve the learning impairment, following the Aβ treatment, and it may lead to an improvement of AD-induced cognitive dysfunction.

Cites

The Concept of Alzheimer’ s Disease in Unani System of Medicine: A Historical Perspective

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APA: Copy

MEHDIZADEH, MEHDI, HASHEM DABAGHIAN, FATANEH, shojaee, Asie, MOLAVI, NIMA, TASLIMI, ZAHRA, SHABANI, RONAK, & SOLEIMANI ASL, SARA. (2017). PROTECTIVE EFFECTS OF CYPERUS ROTUNDUS EXTRACT ON AMYLOID β-PEPTIDE (1-40)-INDUCED MEMORY IMPAIRMENT IN MALE RATS: A BEHAVIORAL STUDY. BASIC AND CLINICAL NEUROSCIENCE, 8(3), 249-254. SID. https://sid.ir/paper/327843/en

Vancouver: Copy

MEHDIZADEH MEHDI, HASHEM DABAGHIAN FATANEH, shojaee Asie, MOLAVI NIMA, TASLIMI ZAHRA, SHABANI RONAK, SOLEIMANI ASL SARA. PROTECTIVE EFFECTS OF CYPERUS ROTUNDUS EXTRACT ON AMYLOID β-PEPTIDE (1-40)-INDUCED MEMORY IMPAIRMENT IN MALE RATS: A BEHAVIORAL STUDY. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2017;8(3):249-254. Available from: https://sid.ir/paper/327843/en

IEEE: Copy

MEHDI MEHDIZADEH, FATANEH HASHEM DABAGHIAN, Asie shojaee, NIMA MOLAVI, ZAHRA TASLIMI, RONAK SHABANI, and SARA SOLEIMANI ASL, “PROTECTIVE EFFECTS OF CYPERUS ROTUNDUS EXTRACT ON AMYLOID β-PEPTIDE (1-40)-INDUCED MEMORY IMPAIRMENT IN MALE RATS: A BEHAVIORAL STUDY,” BASIC AND CLINICAL NEUROSCIENCE, vol. 8, no. 3, pp. 249–254, 2017, [Online]. Available: https://sid.ir/paper/327843/en

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