مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Cites:

1

Information Journal Paper

Title

PROTECTIVE EFFECTS OF ENRICHED ENVIRONMENT AGAINST TRANSIENT CEREBRAL ISCHEMIA-INDUCED IMPAIRMENT OF PASSIVE AVOIDANCE MEMORY AND LONG-TERM POTENTIATION IN RATS

Pages

  443-452

Abstract

 Introduction: ENRICHED ENVIRONMENT (EE), a complex novel environment, has been demonstrated to improve synaptic plasticity in both injured and intact animals. The present study investigated the capacity of an early environmental intervention to normalize the impairment of passive avoidance MEMORY and Long-Term Potentiation (LTP) induced by transient bilateral common carotid artery occlusion (2-vessel occlusion, 2VO) in rats.Methods: After weaning, young Wistar rats (22 days old) were housed in EE or Standard Environment (SE) for 40 days. Transient (30-min) incomplete forebrain ischemia was induced 4 days before the passive avoidance MEMORY test and LTP induction.Results: The transient forebrain ischemia led to impairment of passive avoidance MEMORY and LTP induction in the Perforant Path-Dentate Gyrus (PP-DG) synapses. Interestingly, housing and growing in EE prior to 2VO was found to significantly reverse 2VO-induced cognitive and LTP impairments.Conclusion: Our results suggest that early housing and growing in EE exhibits therapeutic potential to normalize cognitive and LTP abnormalities induced by 2VO ischemic model in rats.

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    • Cite

    APA: Copy

    Ahmadalipour, Ali, SADEGHZADEH, JAFAR, SAMAEI, SEYED AFSHIN, & RASHIDY POUR, ALI. (2017). PROTECTIVE EFFECTS OF ENRICHED ENVIRONMENT AGAINST TRANSIENT CEREBRAL ISCHEMIA-INDUCED IMPAIRMENT OF PASSIVE AVOIDANCE MEMORY AND LONG-TERM POTENTIATION IN RATS. BASIC AND CLINICAL NEUROSCIENCE, 8(6), 443-452. SID. https://sid.ir/paper/327892/en

    Vancouver: Copy

    Ahmadalipour Ali, SADEGHZADEH JAFAR, SAMAEI SEYED AFSHIN, RASHIDY POUR ALI. PROTECTIVE EFFECTS OF ENRICHED ENVIRONMENT AGAINST TRANSIENT CEREBRAL ISCHEMIA-INDUCED IMPAIRMENT OF PASSIVE AVOIDANCE MEMORY AND LONG-TERM POTENTIATION IN RATS. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2017;8(6):443-452. Available from: https://sid.ir/paper/327892/en

    IEEE: Copy

    Ali Ahmadalipour, JAFAR SADEGHZADEH, SEYED AFSHIN SAMAEI, and ALI RASHIDY POUR, “PROTECTIVE EFFECTS OF ENRICHED ENVIRONMENT AGAINST TRANSIENT CEREBRAL ISCHEMIA-INDUCED IMPAIRMENT OF PASSIVE AVOIDANCE MEMORY AND LONG-TERM POTENTIATION IN RATS,” BASIC AND CLINICAL NEUROSCIENCE, vol. 8, no. 6, pp. 443–452, 2017, [Online]. Available: https://sid.ir/paper/327892/en

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