ASSESSING THE EFFECTS OF OPIOIDS ON PATHOLOGICAL MEMORY BY A COMPUTATIONAL MODEL

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BORJKHANI MEHDI; BAHRAMI FARIBA; JANAHMADI MAHYAR

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Journal: Basic and Clinical Neuroscience Year:2018 | Volume:9 | Issue:4 Page(s): 275-287

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Title

ASSESSING THE EFFECTS OF OPIOIDS ON PATHOLOGICAL MEMORY BY A COMPUTATIONAL MODEL

Author(s)

BORJKHANI MEHDI | BAHRAMI FARIBA | JANAHMADI MAHYAR | Issue Writer Certificate

Keywords

OPIOIDS

MEMORY OF ADDICTION

SYNAPTIC PLASTICITY

LONG- TERM POTENTIATION (LTP)

HIPPOCAMPUS

Abstract

Introduction: OPIOIDS hijack learning and memory formation mechanisms of brain and induce a pathological memory in the HIPPOCAMPUS. This effect is mainly mediated by modifications in glutamatergic system. Speaking more precisely, OPIOIDS presence in a synapse inhibits blockage of N-Methyl-D-Aspartate Receptor (NMDAR) by Mg2+, enhances conductance of NMDAR and thus, induces false Long-Term Potentiation (LTP).Methods: Based on experimental observations of different researchers, we developed a mathematical model for a pyramidal neuron of the HIPPOCAMPUS to study this false LTP. The model contains a spine of the pyramidal neuron with NMDAR, α-Amino-3-hydroxy-5-Methyl- 4-isoxazole Propionic Acid Receptors (AMPARs), and Voltage-Gated Calcium Channels (VGCCs). The model also describes Calmodulin-dependent protein Kinase II (CaMKII) and AMPAR phosphorylation processes which are assumed to be the indicators of LTP induction in the synapse.Results: Simulation results indicate that the effect of inhibition of blockage of NMDARs by Mg2+on the false LTP is not as crucial as the effect of NMDAR’s conductance modification by OPIOIDS. We also observed that activation of VGCCs has a dominant role in inducing pathological LTP.Conclusion: Our results confirm that preventing this pathological LTP is possible by three different mechanisms: 1. By decreasing NMDAR’s conductance; and 2. By attenuating VGCC’s mediated current; and 3. By enhancing glutamate clearance rate from the synapse.

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APA: Copy

BORJKHANI, MEHDI, BAHRAMI, FARIBA, & JANAHMADI, MAHYAR. (2018). ASSESSING THE EFFECTS OF OPIOIDS ON PATHOLOGICAL MEMORY BY A COMPUTATIONAL MODEL. BASIC AND CLINICAL NEUROSCIENCE, 9(4), 275-287. SID. https://sid.ir/paper/327899/en

Vancouver: Copy

BORJKHANI MEHDI, BAHRAMI FARIBA, JANAHMADI MAHYAR. ASSESSING THE EFFECTS OF OPIOIDS ON PATHOLOGICAL MEMORY BY A COMPUTATIONAL MODEL. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2018;9(4):275-287. Available from: https://sid.ir/paper/327899/en

IEEE: Copy

MEHDI BORJKHANI, FARIBA BAHRAMI, and MAHYAR JANAHMADI, “ASSESSING THE EFFECTS OF OPIOIDS ON PATHOLOGICAL MEMORY BY A COMPUTATIONAL MODEL,” BASIC AND CLINICAL NEUROSCIENCE, vol. 9, no. 4, pp. 275–287, 2018, [Online]. Available: https://sid.ir/paper/327899/en

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