مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

235
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

132
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

Dopaminergic Modulation of Synaptic Plasticity, Its Role in Neuropsychiatric Disorders, and Its Computational Modeling

Pages

  1-12

Abstract

 Neuromodulators modify intrinsic characteristics of the nervous system in order to reconfigure the functional properties of neural circuits. This reconfiguration is crucial for the flexibility of the nervous system to respond on an input-modulated basis. Such a functional rearrangement is realized by modification of intrinsic properties of the neural circuits including synaptic interactions. Dopamine is an important neuromodulator involved in motivation and stimulusreward learning process, and adjusts synaptic dynamics in multiple time scales through different pathways. The modification of Synaptic plasticity by Dopamine underlies the change in synaptic transmission and integration mechanisms, which affects intrinsic properties of the neural system including membrane excitability, probability of neurotransmitters release, receptors’ response to neurotransmitters, protein trafficking, and gene transcription. Dopamine also plays a central role in behavioral control, whereas its malfunction can cause cognitive disorders. Impaired Dopamine signaling is implicated in several Neuropsychiatric disorders such as Parkinson’ s disease, drug addiction, schizophrenia, attention-deficit/hyperactivity disorder, obsessive-compulsive disorder and Tourette’ s syndrome. Therefore, Dopamine plays a crucial role in the nervous system, where its proper modulation of neural circuits may enhance plasticity-related procedures, but disturbances in Dopamine signaling might be involved in numerous Neuropsychiatric disorders. In recent years, several computational models are proposed to formulate the involvement of Dopamine in Synaptic plasticity or Neuropsychiatric disorders and address their connection based on the experimental findings.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    Madadi Asl, Mojtaba, VAHABIE, ABDOL HOSSEIN, & VALIZADEH, ALIREZA. (2019). Dopaminergic Modulation of Synaptic Plasticity, Its Role in Neuropsychiatric Disorders, and Its Computational Modeling. BASIC AND CLINICAL NEUROSCIENCE, 10(1), 1-12. SID. https://sid.ir/paper/327909/en

    Vancouver: Copy

    Madadi Asl Mojtaba, VAHABIE ABDOL HOSSEIN, VALIZADEH ALIREZA. Dopaminergic Modulation of Synaptic Plasticity, Its Role in Neuropsychiatric Disorders, and Its Computational Modeling. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2019;10(1):1-12. Available from: https://sid.ir/paper/327909/en

    IEEE: Copy

    Mojtaba Madadi Asl, ABDOL HOSSEIN VAHABIE, and ALIREZA VALIZADEH, “Dopaminergic Modulation of Synaptic Plasticity, Its Role in Neuropsychiatric Disorders, and Its Computational Modeling,” BASIC AND CLINICAL NEUROSCIENCE, vol. 10, no. 1, pp. 1–12, 2019, [Online]. Available: https://sid.ir/paper/327909/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button