مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

251
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

151
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neurons of the CA1 Hippocampus in Rat Model of Alzheimer’ s Disease

Pages

  109-118

Abstract

 Introduction: Donepezil (DON), an Acetylcholinesterase Inhibitor (AChEI), is widely used in the treatment of Alzheimer’ s Disease (AD). The current study aimed at evaluating the effect of Donepezil hydrochloride on pyramidal neuron response in CA1 region of a rat model of AD. Methods: In the current experimental study, adult male Wistar Rats were randomly divided into four groups: Nucleus Basalis Magnocellularis (NBM) lesion (the lesions were induced by an electrical method of 0. 5 m A, for 3 s in NBM) and three Donepezil groups (lesions plus 5, 10, and 15 mg/kg Donepezil intraperitoneal injection). Neuronal spontaneous activity to injection of the Donepezil and saline were recorded in CA1 region of hippocampal. Results: The obtained results showed that IntraPeritoneal (IP) injection of Donepezil (10 and 15 mg/kg) increased neuronal spontaneous activity in the rat model of AD. Conclusion: The current study results suggested that acute IP injection of Donepezil increased neuronal response in CA1 region of hippocampal in a rat model of AD.

Cites

References

  • No record.

    • Cite

    APA: Copy

    ESKANDARY, AZADE, MOAZEDI, AHMAD ALI, Najaph Zade, Hosein, & AKHOND, MOHAMAD REZA. (2019). Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neurons of the CA1 Hippocampus in Rat Model of Alzheimer’ s Disease. BASIC AND CLINICAL NEUROSCIENCE, 10(2), 109-118. SID. https://sid.ir/paper/327916/en

    Vancouver: Copy

    ESKANDARY AZADE, MOAZEDI AHMAD ALI, Najaph Zade Hosein, AKHOND MOHAMAD REZA. Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neurons of the CA1 Hippocampus in Rat Model of Alzheimer’ s Disease. BASIC AND CLINICAL NEUROSCIENCE[Internet]. 2019;10(2):109-118. Available from: https://sid.ir/paper/327916/en

    IEEE: Copy

    AZADE ESKANDARY, AHMAD ALI MOAZEDI, Hosein Najaph Zade, and MOHAMAD REZA AKHOND, “Effects of Donepezil Hydrochloride on Neuronal Response of Pyramidal Neurons of the CA1 Hippocampus in Rat Model of Alzheimer’ s Disease,” BASIC AND CLINICAL NEUROSCIENCE, vol. 10, no. 2, pp. 109–118, 2019, [Online]. Available: https://sid.ir/paper/327916/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button