DETECTION OF NOVEL MUTATION IN LUKS PANTON-VALENTINE LEUKOCIDIN GENE IN TWELVE ISOLATES OF STAPHYLOCOCCUS AUREUS FROM SUDANESE PATIENTS

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MOHAMMED OSMAN NAJEM ALDIN; ELRAYAH INTISAR ELHAG; ALTAYB HISHAM; ELHAJ NIHAD MOHAMMED; SALIH MOHAMED AHMED; ABUZEID NADIR; ELDIRDERY MUATAZ MOHMED; MOHAMED YASSIR MAHGOUB

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Journal: INTERNATIONAL JOURNAL OF MOLECULAR AND CLINICAL MICROBIOLOGY Year:2016 | Volume:6 | Issue:2 Page(s): 663-669

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Title

DETECTION OF NOVEL MUTATION IN LUKS PANTON-VALENTINE LEUKOCIDIN GENE IN TWELVE ISOLATES OF STAPHYLOCOCCUS AUREUS FROM SUDANESE PATIENTS

Author(s)

Keywords

S. AUREUS

PVL

LUKS-PV

MUTATION

SUDANESE

Abstract

Staphylococcus aureus carrying PVL gene remain major health problem associated with highly virulent infections. Characterization of such gene is important to know the impact and the functional significance of nucleotide variations. PCR and standard sequencing were performed for twelve SUDANESE strains from different sources. Protein structures prediction, modeling and physiochemical analysis were done to analyze genetic variation in PVL. Single nucleotide polymorphism at position 610 (A/G) of LUKS-PV was detected in all tested isolates resulted in nonsynonymous MUTATION in the amino acid sequence at position 204 (N / D). Using molecular and bioinformatics tools the detected novel MUTATION in LUKS-PV may have a diagnostic functional significance.

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APA: Copy

MOHAMMED OSMAN, NAJEM ALDIN, ELRAYAH, INTISAR ELHAG, ALTAYB, HISHAM, ELHAJ, NIHAD MOHAMMED, SALIH, MOHAMED AHMED, ABUZEID, NADIR, ELDIRDERY, MUATAZ MOHMED, & MOHAMED, YASSIR MAHGOUB. (2016). DETECTION OF NOVEL MUTATION IN LUKS PANTON-VALENTINE LEUKOCIDIN GENE IN TWELVE ISOLATES OF STAPHYLOCOCCUS AUREUS FROM SUDANESE PATIENTS. INTERNATIONAL JOURNAL OF MOLECULAR AND CLINICAL MICROBIOLOGY, 6(2), 663-669. SID. https://sid.ir/paper/328143/en

Vancouver: Copy

MOHAMMED OSMAN NAJEM ALDIN, ELRAYAH INTISAR ELHAG, ALTAYB HISHAM, ELHAJ NIHAD MOHAMMED, SALIH MOHAMED AHMED, ABUZEID NADIR, ELDIRDERY MUATAZ MOHMED, MOHAMED YASSIR MAHGOUB. DETECTION OF NOVEL MUTATION IN LUKS PANTON-VALENTINE LEUKOCIDIN GENE IN TWELVE ISOLATES OF STAPHYLOCOCCUS AUREUS FROM SUDANESE PATIENTS. INTERNATIONAL JOURNAL OF MOLECULAR AND CLINICAL MICROBIOLOGY[Internet]. 2016;6(2):663-669. Available from: https://sid.ir/paper/328143/en

IEEE: Copy

NAJEM ALDIN MOHAMMED OSMAN, INTISAR ELHAG ELRAYAH, HISHAM ALTAYB, NIHAD MOHAMMED ELHAJ, MOHAMED AHMED SALIH, NADIR ABUZEID, MUATAZ MOHMED ELDIRDERY, and YASSIR MAHGOUB MOHAMED, “DETECTION OF NOVEL MUTATION IN LUKS PANTON-VALENTINE LEUKOCIDIN GENE IN TWELVE ISOLATES OF STAPHYLOCOCCUS AUREUS FROM SUDANESE PATIENTS,” INTERNATIONAL JOURNAL OF MOLECULAR AND CLINICAL MICROBIOLOGY, vol. 6, no. 2, pp. 663–669, 2016, [Online]. Available: https://sid.ir/paper/328143/en

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