CLONIDINE: AN OLD FRIEND NEWLY REDISCOVERED

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DABBAGH ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Anesthesiology and Pain Medicine Year:2011 | Volume:1 | Issue:1 (1) Page(s): 8-9

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Information Journal Paper

Title

CLONIDINE: AN OLD FRIEND NEWLY REDISCOVERED

Author(s)

DABBAGH ALI | Issue Writer Certificate

Keywords

CLONIDINE

ANESTHESIA

ANALGESICS

Abstract

A number of decades have passed since the beginning of clinical use of CLONIDINE. Nowadays, there is growing role defined for CLONIDINE, an alpha-2 adrenergic agonist, used originally as an antihypertensive drug and then, as an oral, intravenous or now, an intrathecal agent.This drug would surpass the blood-brain barrier to target the central alpha 2 adrenoceptors to affect the CNS by decreasing the brain sympathetic tone; this would result in decreased systolic and diastolic blood pressure and heart rate. However, central alpha 2 adrenoceptor agonistic effects is not the only route for CLONIDINE, because the drug has intrathecal effects when administered as an adjuvant during spinal or epidural ANESTHESIA (combined with local anesthetics). Besides, its peripheral effects have been described fully. There are a number of studies well demonstrating that oral CLONIDINE as a pretreatment to ANESTHESIA, can increase the quality of perioperative sedation and analgesia while having just a few side effects.

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APA: Copy

DABBAGH, ALI. (2011). CLONIDINE: AN OLD FRIEND NEWLY REDISCOVERED. ANESTHESIOLOGY AND PAIN MEDICINE, 1(1 (1)), 8-9. SID. https://sid.ir/paper/328398/en

Vancouver: Copy

DABBAGH ALI. CLONIDINE: AN OLD FRIEND NEWLY REDISCOVERED. ANESTHESIOLOGY AND PAIN MEDICINE[Internet]. 2011;1(1 (1)):8-9. Available from: https://sid.ir/paper/328398/en

IEEE: Copy

ALI DABBAGH, “CLONIDINE: AN OLD FRIEND NEWLY REDISCOVERED,” ANESTHESIOLOGY AND PAIN MEDICINE, vol. 1, no. 1 (1), pp. 8–9, 2011, [Online]. Available: https://sid.ir/paper/328398/en

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