COMMON MUTATIONS IN EXON 10 OF RET PROTO-ONCOGENE IN PATIENTS WITH MEDULLAR THYROID CARCINOMA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

REZGHI BAREZ SH.; ZARIF YEGANE M.; SHEYKHOL ESLAMI S.; HOGHOUGHI RAD L.; AZIZI F.; HEDAYATI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: KOWSAR MEDICAL JOURNAL Year:2011 | Volume:16 | Issue:2 Page(s): 73-78

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

1,197

Download:

Cites:

Information Journal Paper

Title

COMMON MUTATIONS IN EXON 10 OF RET PROTO-ONCOGENE IN PATIENTS WITH MEDULLAR THYROID CARCINOMA

Author(s)

Keywords

MEDULLARY THYROID CARCINOMAQ2

RET PROTO-ONCOGENEQ2

GERM-LINE MUTATIONQ3

EXON 10Q2

Abstract

Aims: MEDULLARY THYROID CARCINOMA accounts for 5-10% of total types of thyroid cancers. An important role of mutations in the RET PROTO-ONCOGENE in MTC has been well identified. The purpose of this study was to determine the prevalence of seven common GERM-LINE MUTATIONs of the RET PROTO-ONCOGENE in EXON 10 in Iranian MTC patients.Materials & Methods: This descriptive study was performed in year 2009-2010. The study population was 217 MTC patients and their first-degree relatives who were selected by simple sampling method. Genomic DNA content of peripheral blood was extracted according to standard salting out/Proteinase K method. Mutation detection in RET PROTO-ONCOGENE in EXON 10 was assessed through PCR-RFLP method.Results: In 217 individuals (Female: Male 1.4: 1, mean age 33.4±15.8 years), 9 mutations were identified at codons 618 (7 mutations) and 620 (2 mutations) in RET PROTO-ONCOGENE EXON 10. The most common amino-acid change was Cys618Phe. In addition, no mutation was found in codon 611.Conclusion: The mutations frequency of the RET PROTO-ONCOGENE in EXON 10 is 6% in the studied population.Accordingly, existence of the common mutations in the RET PROTO-ONCOGENE in all MTC patients and their families is recommended particularly in other exons (11, 12, 13, 14, 15, 16) with a direct DNA sequencing method.

Cites

IMPORTANCE OF EPIGENETIC CHANGES IN THE THYROID CANCER INCIDENCE AND THEIR THERAPEUTIC APPLICATIONS (REVIEW ARTICLE)

References

No record.

Cite

APA: Copy

REZGHI BAREZ, SH., ZARIF YEGANE, M., SHEYKHOL ESLAMI, S., HOGHOUGHI RAD, L., AZIZI, F., & HEDAYATI, M.. (2011). COMMON MUTATIONS IN EXON 10 OF RET PROTO-ONCOGENE IN PATIENTS WITH MEDULLAR THYROID CARCINOMA. KOWSAR MEDICAL JOURNAL, 16(2), 73-78. SID. https://sid.ir/paper/32918/en

Vancouver: Copy

REZGHI BAREZ SH., ZARIF YEGANE M., SHEYKHOL ESLAMI S., HOGHOUGHI RAD L., AZIZI F., HEDAYATI M.. COMMON MUTATIONS IN EXON 10 OF RET PROTO-ONCOGENE IN PATIENTS WITH MEDULLAR THYROID CARCINOMA. KOWSAR MEDICAL JOURNAL[Internet]. 2011;16(2):73-78. Available from: https://sid.ir/paper/32918/en

IEEE: Copy

SH. REZGHI BAREZ, M. ZARIF YEGANE, S. SHEYKHOL ESLAMI, L. HOGHOUGHI RAD, F. AZIZI, and M. HEDAYATI, “COMMON MUTATIONS IN EXON 10 OF RET PROTO-ONCOGENE IN PATIENTS WITH MEDULLAR THYROID CARCINOMA,” KOWSAR MEDICAL JOURNAL, vol. 16, no. 2, pp. 73–78, 2011, [Online]. Available: https://sid.ir/paper/32918/en

Related Journal Papers