ASSOCIATION OF CODON 72 OF P53 GENE POLYMORPHISM WITH CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY

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GERAYLI SINA; PASDAR ALIREZA; ROSTAMI SINA; SEPAHI SAMANEH; HOSEINI SEYED MOUSALREZA; AHADI MITRA; JAHANIAN REZA; GHOLOOBI AIDA; MESHKAT ZAHRA

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Journal: JOURNAL OF CELL AND MOLECULAR RESEARCH Year:2016 | Volume:8 | Issue:2 Page(s): 46-51

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Title

ASSOCIATION OF CODON 72 OF P53 GENE POLYMORPHISM WITH CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY

Author(s)

Keywords

POLYMORPHISM

P 53 GENE

HCV

GENETIC EPIDEMIOLOGY

IRAN

Abstract

Single nucleotide POLYMORPHISM in codon 72 ofp53 gene (Arg/Pro) changes p53 protein structure and affects its activities. Hepatitis C virus (HCV) is believed to induce hepatocellular carcinoma andP53 POLYMORPHISMs have been associated with human cancers. The aim of this study was to evaluate genetic variants of codon 72 of p53 gene POLYMORPHISM in HCV patients and its relationship with HCV infection. The study was conducted on 67 HCV patients, who were referred to medical centers of Mashhad city, IRAN, and 73 healthy people from the same region.Genotyping of codon 72 of p53 gene was performed by PCR-RFLP method. The distributions of different alleles of p53POLYMORPHISMs did not differ significantly between groups. The respective proportions of Proline homozygotes, heterozygotes, and Arginine homozygotes were 37.31%, 35.82%, 26.86% in patients and 39.72%, 27.39%, and 32.87% in the control group respectively. However, we found no significant difference for the allelic or genotype distribution between cases and controls. Our results indicated no strong evidence of association of thep53 POLYMORPHISM with HCV infection; however, further investigation is needed in different ethnic groups to elucidate the role of this POLYMORPHISM in HCV infection.

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APA: Copy

GERAYLI, SINA, PASDAR, ALIREZA, ROSTAMI, SINA, SEPAHI, SAMANEH, HOSEINI, SEYED MOUSALREZA, AHADI, MITRA, JAHANIAN, REZA, GHOLOOBI, AIDA, & MESHKAT, ZAHRA. (2016). ASSOCIATION OF CODON 72 OF P53 GENE POLYMORPHISM WITH CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY. JOURNAL OF CELL AND MOLECULAR RESEARCH, 8(2), 46-51. SID. https://sid.ir/paper/329282/en

Vancouver: Copy

GERAYLI SINA, PASDAR ALIREZA, ROSTAMI SINA, SEPAHI SAMANEH, HOSEINI SEYED MOUSALREZA, AHADI MITRA, JAHANIAN REZA, GHOLOOBI AIDA, MESHKAT ZAHRA. ASSOCIATION OF CODON 72 OF P53 GENE POLYMORPHISM WITH CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY. JOURNAL OF CELL AND MOLECULAR RESEARCH[Internet]. 2016;8(2):46-51. Available from: https://sid.ir/paper/329282/en

IEEE: Copy

SINA GERAYLI, ALIREZA PASDAR, SINA ROSTAMI, SAMANEH SEPAHI, SEYED MOUSALREZA HOSEINI, MITRA AHADI, REZA JAHANIAN, AIDA GHOLOOBI, and ZAHRA MESHKAT, “ASSOCIATION OF CODON 72 OF P53 GENE POLYMORPHISM WITH CHRONIC HEPATITIS C VIRUS INFECTION: A CASE CONTROL STUDY,” JOURNAL OF CELL AND MOLECULAR RESEARCH, vol. 8, no. 2, pp. 46–51, 2016, [Online]. Available: https://sid.ir/paper/329282/en

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