CEREBRAL BLOOD FLOW MEASUREMENTS DURING NALOXONE-PRECIPITATED MORPHINE WITHDRAWAL IN DEPENDENT RATS

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ZAMANI R.; SEMNANIAN S.; HAJIZADEH S.; FATH ELAHI Y.

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Journal: KOWSAR MEDICAL JOURNAL Year:2001 | Volume:6 | Issue:part 2 Page(s): 103-110

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Title

CEREBRAL BLOOD FLOW MEASUREMENTS DURING NALOXONE-PRECIPITATED MORPHINE WITHDRAWAL IN DEPENDENT RATS

Author(s)

ZAMANI R. | SEMNANIAN S. | HAJIZADEH S. | FATH ELAHI Y. | Issue Writer Certificate

Keywords

MORPHINEQ3

WITHDRAWAL SYNDROMEQ3

CEREBRAL BLOOD FLOWQ4

LASER-DOPPLER FLOWMETRYQ4

Abstract

Laser-Doppler flowmetry (LDF) was used to measure changes in regional cerebral blood flow (rCBF) following MORPHINE and naloxone administration in MORPHINE-dependent anesthetized rats. MORPHINE (10 mg/kg; i.p.) administration reduced rCBF in control, sham-operated and MORPHINE-dependent rats, but the depressant effect of MORPHINE in MORPHINE-dependent animals was less than that of controls and sham-operated groups. While naloxone (0.5 mg/kg; s.c.) had no considerable effect on rCBF in control and sham-operated groups, it increased rCBF in MORPHINE dependent ones. The depressant effect of MORPHINE in the naive group and the enhancing effect of naloxone in MORPHINE-dependent animals were not seen after local application of lidocaine upon the recording site. This study may provide a framework to study the cellular and molecular mechanisms responsible for coupling neuronal electrical activity with regional alteration in blood flow during precipitation of MORPHINE withdrawal.

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APA: Copy

ZAMANI, R., SEMNANIAN, S., HAJIZADEH, S., & FATH ELAHI, Y.. (2001). CEREBRAL BLOOD FLOW MEASUREMENTS DURING NALOXONE-PRECIPITATED MORPHINE WITHDRAWAL IN DEPENDENT RATS. KOWSAR MEDICAL JOURNAL, 6(part 2), 103-110. SID. https://sid.ir/paper/32938/en

Vancouver: Copy

ZAMANI R., SEMNANIAN S., HAJIZADEH S., FATH ELAHI Y.. CEREBRAL BLOOD FLOW MEASUREMENTS DURING NALOXONE-PRECIPITATED MORPHINE WITHDRAWAL IN DEPENDENT RATS. KOWSAR MEDICAL JOURNAL[Internet]. 2001;6(part 2):103-110. Available from: https://sid.ir/paper/32938/en

IEEE: Copy

R. ZAMANI, S. SEMNANIAN, S. HAJIZADEH, and Y. FATH ELAHI, “CEREBRAL BLOOD FLOW MEASUREMENTS DURING NALOXONE-PRECIPITATED MORPHINE WITHDRAWAL IN DEPENDENT RATS,” KOWSAR MEDICAL JOURNAL, vol. 6, no. part 2, pp. 103–110, 2001, [Online]. Available: https://sid.ir/paper/32938/en

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