Effect of the Mixed Herbal Medicines Extract (Fennel, Chamomile, and Saffron) on Menopause Syndrome: a Randomized Controlled Clinical Trial

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MAHDAVIAN MITRA; Mirzaii Najmabadi Khadijeh; HOSSEINZADEH HOSSEIN; Mirzaeian Sara; BADIEE AVAL SHAPOUR; Esmaeeli Habibollah

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Journal Paper

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Journal: Journal of Caring Sciences Year:2019 | Volume:8 | Issue:3 Page(s): 181-189

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Title

Effect of the Mixed Herbal Medicines Extract (Fennel, Chamomile, and Saffron) on Menopause Syndrome: a Randomized Controlled Clinical Trial

Author(s)

Keywords

Menopause

Herbal Medicines

Alternative Medicines

Menopause Rating Scale

Abstract

Introduction: . Menopause is the transition from the reproductive phase of a woman to the non-reproductive. It may impair quality of life. The study aims to determine the effectiveness of mixed Herbal Medicines on Menopause symptoms Methods: A randomized, triple-blind, clinical trial and placebo-controlled study on 120 peri-menopausal women aged 45-65 years for 12 weeks. All participants took herbal extracts drops orally daily and randomly allocated into four groups: placebo (C), A (250 mg chamomile, 30 mg fennel, 15 mg saffron), B (1000 mg, 120 mg, 60 mg), and D (500 mg, 60 mg, 30 mg). Primary outcome was the mean change in scores of the Menopause rating scale that evaluates 11 symptoms. Results: The median (IQR) physical score significantly reduced from 8. 5(4) to 2(3), in psych score reduced from 12(4) to 2 (2) and in urogenital score reduced from 6. 5(3) to 3(2) in group B. In group D physical score decreased from 12(6) to 8(4), in psychological score reduced from12 (3) to 8(4) and urogenital score reduced from 7. 5 (3) to 8(3) at week 12. No significant differences in group A and C. With comparison the scores of physical, psych and urogenital domain of MRS questionnaire in 1th, 6th and 12th, no significant difference within group A and C were seen, but statistically significant difference was within group B (p< 0. 001) and D (p< 0. 001) in all weeks. The effect size was 0. 92. Conclusion: A 12 weeks extracts treatment, there were significant improvement in physical, psychological and urogenital domains in group B.

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APA: Copy

MAHDAVIAN, MITRA, Mirzaii Najmabadi, Khadijeh, HOSSEINZADEH, HOSSEIN, Mirzaeian, Sara, BADIEE AVAL, SHAPOUR, & Esmaeeli, Habibollah. (2019). Effect of the Mixed Herbal Medicines Extract (Fennel, Chamomile, and Saffron) on Menopause Syndrome: a Randomized Controlled Clinical Trial. JOURNAL OF CARING SCIENCES, 8(3), 181-189. SID. https://sid.ir/paper/329667/en

Vancouver: Copy

MAHDAVIAN MITRA, Mirzaii Najmabadi Khadijeh, HOSSEINZADEH HOSSEIN, Mirzaeian Sara, BADIEE AVAL SHAPOUR, Esmaeeli Habibollah. Effect of the Mixed Herbal Medicines Extract (Fennel, Chamomile, and Saffron) on Menopause Syndrome: a Randomized Controlled Clinical Trial. JOURNAL OF CARING SCIENCES[Internet]. 2019;8(3):181-189. Available from: https://sid.ir/paper/329667/en

IEEE: Copy

MITRA MAHDAVIAN, Khadijeh Mirzaii Najmabadi, HOSSEIN HOSSEINZADEH, Sara Mirzaeian, SHAPOUR BADIEE AVAL, and Habibollah Esmaeeli, “Effect of the Mixed Herbal Medicines Extract (Fennel, Chamomile, and Saffron) on Menopause Syndrome: a Randomized Controlled Clinical Trial,” JOURNAL OF CARING SCIENCES, vol. 8, no. 3, pp. 181–189, 2019, [Online]. Available: https://sid.ir/paper/329667/en

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