EFFICACY OF INTRAVENOUS MAGNESIUM SULFATE IN REDUCING VENTRICULAR ARRHYTHMIA AFTER ACUTE MYOCARDIAL INFARCTION

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KAZEMI SALEH D.; ORAEI S.

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Journal: KOWSAR MEDICAL JOURNAL Year:2001 | Volume:6 | Issue:part 3 Page(s): 191-196

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Title

EFFICACY OF INTRAVENOUS MAGNESIUM SULFATE IN REDUCING VENTRICULAR ARRHYTHMIA AFTER ACUTE MYOCARDIAL INFARCTION

Author(s)

KAZEMI SALEH D. | ORAEI S. | Issue Writer Certificate

Keywords

ACUTE MYOCARDIAL INFARCTIONQ4

MAGNESIUM SALFATEQ3

VENTRICULAR ARRHYTEMIAQ4

AMI MORTALITYQ4

Abstract

Intravenous infusion of magnesium sulfate during aucte myocardial infarction (AMI) has been shown to be benefical in many studies. However, These effect are not consistent from one trial to another, and its mechanism of action is not clearly understood. This is an intrim report of Multicentric placebo-controlled double blinded study to define the role of magnesium sulfate in reducing ventricular arrhythmias and mortality after AMI. 200 Consecutive patients with AMI were randomly allocated to receive either an intravenous load of 8 mmol magnesium sulfate over five minutes followed by 65 mmol over the next 24 hours (group A) or equal volumes of saline (group B). 151 cases (77.5% men, age 12-58 years) completed the course of treatment. Patients were monitored during the first 48 hours of patients CCU admission (69% of group A vs 65.8% of group B). There was no significant difference between the two groups regarding age, sex, prevalence of risk factors, Killip classification of functional status or the rate of adminstration of thrombolytic drugs. Sustained ventricular tachycardia was observed in none of group A patients but occurred in four patients of group B (5.1%). Ventricular fibrillation occurred in two cases of each group (25%). Other ventricular fibrillations occurred in two cases of each group (25%). Other ventricular arrhythmias were documented in 4.2% of group A vs 6.4% group B. During the first 48 hours, death occured in 6.3% of group A and 8.3% of group B patients. Despite the observed trends, none of the above mentioned finding are statistically significant but a composite endpoint of recurrent angina infarction, hypotension or heart failure occurred in 6.9% of group A vs 24% of group B and was statistjcally significant (P<0.01). This study showed some beneficial effect of intravenous infusion of magnesium sulfate on reducing the early complications of AMI, but suppression of dangerous arrhythmias does not seem to be the responsible mechanism.

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AN EPIDEMIOLOGICAL MODEL (MARKOV CHAIN) OF CARDIOVASCULAR DISEASE IN IRAN

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APA: Copy

KAZEMI SALEH, D., & ORAEI, S.. (2001). EFFICACY OF INTRAVENOUS MAGNESIUM SULFATE IN REDUCING VENTRICULAR ARRHYTHMIA AFTER ACUTE MYOCARDIAL INFARCTION. KOWSAR MEDICAL JOURNAL, 6(part 3), 191-196. SID. https://sid.ir/paper/33004/en

Vancouver: Copy

KAZEMI SALEH D., ORAEI S.. EFFICACY OF INTRAVENOUS MAGNESIUM SULFATE IN REDUCING VENTRICULAR ARRHYTHMIA AFTER ACUTE MYOCARDIAL INFARCTION. KOWSAR MEDICAL JOURNAL[Internet]. 2001;6(part 3):191-196. Available from: https://sid.ir/paper/33004/en

IEEE: Copy

D. KAZEMI SALEH, and S. ORAEI, “EFFICACY OF INTRAVENOUS MAGNESIUM SULFATE IN REDUCING VENTRICULAR ARRHYTHMIA AFTER ACUTE MYOCARDIAL INFARCTION,” KOWSAR MEDICAL JOURNAL, vol. 6, no. part 3, pp. 191–196, 2001, [Online]. Available: https://sid.ir/paper/33004/en

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