CHROMOSOMAL SENSITIVITY TO IONISING RADIATION IN LYMPHOCYTES OF PATIENTS WITH HEAD AND NECK CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

FARHAN FARSHID; MAHMOODI MAJID; AZIMI CYRUS; MOHAGHEGHI MOHAMMAD ALI; FARZANFAR FARIDEH; NOORMOHAMMADI AZAM; KHALEGHIAN MALIHEA; ESFAHANI MAHBOD; JAFARI ABBAS; SAFARI ZAHRA; DIVSALAR KOUROS

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Basic & Clinical Cancer Research Year:2015 | Volume:7 | Issue:4 Page(s): 2-8

Download Full-Text

View:

294

Download:

103

Cites:

Information Journal Paper

Title

CHROMOSOMAL SENSITIVITY TO IONISING RADIATION IN LYMPHOCYTES OF PATIENTS WITH HEAD AND NECK CANCER

Author(s)

Keywords

HEAD AND NECK CANCER

GAMMA IRRADIATION

G2 ASSAY

MICRONUCLEI ASSAY

Abstract

Background: The aim of this study was to test the in vitro sensitivity of lymphocytes of patients with HEAD AND NECK CANCER against GAMMA IRRADIATION and also to find out if the frequencies of chromosomal aberrations correlate with side effects of radiotherapy.Methods: Peripheral blood of 101 patients with HEAD AND NECK CANCER was collected before the onset of radiotherapy, cultured and irradiated in the G-2 or the G-0 phase of the cell cycle. Lymphocytes of 40 healthy donors were treated in the same way. Chromosomal aberrations such as chromosome and chromatid breakages, chromosome and chromatid gaps, chromatid exchanges and micronuclei were scored in metaphase cells of the patient and control groups.Results: The frequency of radiation- induced G2 aberrations in lymphocytes of patients were on average higher than that of healthy donors (P=0.001 for chromosomal breaks). The frequency of radiation-induced micronuclei in the G0 assay were also higher in patients than that in controls (P=0.05). The results also indicate that there is no correlation between the two assays. No significant correlation was observed between aberration frequencies in lymphocytes and the degree of both early and late normal tissue reactions.Conclusion: The induced chromosomal aberration frequencies in lymphocytes of patients with HEAD AND NECK CANCER are higher than those in healthy individuals, however, it does not appear to have a predictive value for the risk of developing side effects to radiotherapy.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

FARHAN, FARSHID, MAHMOODI, MAJID, AZIMI, CYRUS, MOHAGHEGHI, MOHAMMAD ALI, FARZANFAR, FARIDEH, NOORMOHAMMADI, AZAM, KHALEGHIAN, MALIHEA, ESFAHANI, MAHBOD, JAFARI, ABBAS, SAFARI, ZAHRA, & DIVSALAR, KOUROS. (2015). CHROMOSOMAL SENSITIVITY TO IONISING RADIATION IN LYMPHOCYTES OF PATIENTS WITH HEAD AND NECK CANCER. BASIC & CLINICAL CANCER RESEARCH, 7(4), 2-8. SID. https://sid.ir/paper/330195/en

Vancouver: Copy

FARHAN FARSHID, MAHMOODI MAJID, AZIMI CYRUS, MOHAGHEGHI MOHAMMAD ALI, FARZANFAR FARIDEH, NOORMOHAMMADI AZAM, KHALEGHIAN MALIHEA, ESFAHANI MAHBOD, JAFARI ABBAS, SAFARI ZAHRA, DIVSALAR KOUROS. CHROMOSOMAL SENSITIVITY TO IONISING RADIATION IN LYMPHOCYTES OF PATIENTS WITH HEAD AND NECK CANCER. BASIC & CLINICAL CANCER RESEARCH[Internet]. 2015;7(4):2-8. Available from: https://sid.ir/paper/330195/en

IEEE: Copy

FARSHID FARHAN, MAJID MAHMOODI, CYRUS AZIMI, MOHAMMAD ALI MOHAGHEGHI, FARIDEH FARZANFAR, AZAM NOORMOHAMMADI, MALIHEA KHALEGHIAN, MAHBOD ESFAHANI, ABBAS JAFARI, ZAHRA SAFARI, and KOUROS DIVSALAR, “CHROMOSOMAL SENSITIVITY TO IONISING RADIATION IN LYMPHOCYTES OF PATIENTS WITH HEAD AND NECK CANCER,” BASIC & CLINICAL CANCER RESEARCH, vol. 7, no. 4, pp. 2–8, 2015, [Online]. Available: https://sid.ir/paper/330195/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops