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Information Journal Paper

Title

Evaluating Gelsolin Gene Expression Among Iranian Breast Cancer Patients

Pages

  16-25

Abstract

 Background: breast cancer is the most common type of cancer among women, and is among the five most prevalent cancer types among Iranian women. Advanced-stage breast cancer is often correlated with distant metastases. Alterations in gene expression affect general cytoskeleton changes during differentiation and oncogenesis, and can be considered an important factor in tumor progression. Gelsolin plays a significant role in actin assembly and has been introduced as a tumor activator. The aim of this study was to evaluate the expression of Gelsolin in breast cancer as well as its correlation with patients’ clinical parameters. Methods: In this study, 70 breast cancer patients, who had been referred to Cancer Institute, Imam Khomeini Hospital Complex for surgery were randomly selected. Normal and tumor tissues were prepared and stored at-80° C. Gelsolin gene expression was measured using real-time polymerase chain reaction (PCR). Results: The results showed that Gelsolin gene expression had increased in 68. 6% of the tumor samples. In addition, there was a significant association between increased levels of gene expression and tumor progression stages (P < 0. 05). However, there was no significant association between increased levels of gene expression and other clinical findings, such as tumor grade, tumor size or patient age. Conclusion: The results revealed that Gelsolin gene expression had increased in the tumor samples. Gelsolin overexpression also resulted in increased lymph node involvement in breast cancer. The expression of this gene also increased significantly during advanced stages of breast cancer; however, there was no significant relation between gelsolin expression and tumor grade or tumor size.

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    • Cite

    APA: Copy

    Tutunchi, Sara, SAFFARI, MOJTABA, MAZAHERI, MAHTA, Nourmohammadi, Parisa, MEMARI, FEREIDOON, & SHIRKOOHI, REZA. (2018). Evaluating Gelsolin Gene Expression Among Iranian Breast Cancer Patients. BASIC & CLINICAL CANCER RESEARCH, 10(4), 16-25. SID. https://sid.ir/paper/330215/en

    Vancouver: Copy

    Tutunchi Sara, SAFFARI MOJTABA, MAZAHERI MAHTA, Nourmohammadi Parisa, MEMARI FEREIDOON, SHIRKOOHI REZA. Evaluating Gelsolin Gene Expression Among Iranian Breast Cancer Patients. BASIC & CLINICAL CANCER RESEARCH[Internet]. 2018;10(4):16-25. Available from: https://sid.ir/paper/330215/en

    IEEE: Copy

    Sara Tutunchi, MOJTABA SAFFARI, MAHTA MAZAHERI, Parisa Nourmohammadi, FEREIDOON MEMARI, and REZA SHIRKOOHI, “Evaluating Gelsolin Gene Expression Among Iranian Breast Cancer Patients,” BASIC & CLINICAL CANCER RESEARCH, vol. 10, no. 4, pp. 16–25, 2018, [Online]. Available: https://sid.ir/paper/330215/en

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