ASSOCIATION BETWEEN A561C POLYMORPHISM OF E-SELECTIN GENE AND CORONARY ARTERIAL DISEASE IN SOUTHEASTERN IRANIAN POPULATION

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NAKHAEE ALIREZA; AFZALI MASOUMEH; TABATABAEI SEYED PEYMAN; TIRGAR FAKHERI KOUROSH; HASHEMI MOHAMMAD

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Journal: Health Scope Year:2013 | Volume:2 | Issue:1 Page(s): 47-51

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Title

ASSOCIATION BETWEEN A561C POLYMORPHISM OF E-SELECTIN GENE AND CORONARY ARTERIAL DISEASE IN SOUTHEASTERN IRANIAN POPULATION

Author(s)

Keywords

CORONARY ARTERY DISEASE

E-SELECTIN

POLYMORPHISM

GENETIC

Abstract

Background: Numerous factors including GENETIC factors play a role in pathogenesis of coronary atherosclerosis. It has been reported that POLYMORPHISMs of genes encoding adhesion molecules are associated with atherosclerosis.Objectives: The present research aimed to evaluate A561C POLYMORPHISM of the E-SELECTIN gene in patients with coronary arterial diseases (CAD).Materials and Methods: Eighty seven CAD patients and 93 age- and sex-matched control subjects were enrolled in this research. The POLYMORPHISM of A561C in the E-SELECTIN gene was defined by polymerase chain reaction followed by restriction fragment length POLYMORPHISM (PCR-RFLP).Results: The prevalence’s of AA, AC and CC genotypes were 55.2%, 24.1% and 20.7% in CAD patients and 51.6%, 40.9% and 7.5% in the control subjects, respectively. The frequencies of the C allele were significantly higher in CAD patients compared with control groups (P & lt; 0.05). Logistic regression analysis revealed a significant association between the C allele and the risk of CAD (OR=1.61, 95%CI=1.03-2.51).Conclusions: Our results displayed that presence of C allele at position 561 E-selection gene is associated with increased risk of atherosclerosis disease in the southeastern Iranian population. This POLYMORPHISM may be able to affect leukocyte-endothelial interactions, which may account for the pathogenesis of atherosclerosis.

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APA: Copy

NAKHAEE, ALIREZA, AFZALI, MASOUMEH, TABATABAEI, SEYED PEYMAN, TIRGAR FAKHERI, KOUROSH, & HASHEMI, MOHAMMAD. (2013). ASSOCIATION BETWEEN A561C POLYMORPHISM OF E-SELECTIN GENE AND CORONARY ARTERIAL DISEASE IN SOUTHEASTERN IRANIAN POPULATION. HEALTH SCOPE, 2(1), 47-51. SID. https://sid.ir/paper/330342/en

Vancouver: Copy

NAKHAEE ALIREZA, AFZALI MASOUMEH, TABATABAEI SEYED PEYMAN, TIRGAR FAKHERI KOUROSH, HASHEMI MOHAMMAD. ASSOCIATION BETWEEN A561C POLYMORPHISM OF E-SELECTIN GENE AND CORONARY ARTERIAL DISEASE IN SOUTHEASTERN IRANIAN POPULATION. HEALTH SCOPE[Internet]. 2013;2(1):47-51. Available from: https://sid.ir/paper/330342/en

IEEE: Copy

ALIREZA NAKHAEE, MASOUMEH AFZALI, SEYED PEYMAN TABATABAEI, KOUROSH TIRGAR FAKHERI, and MOHAMMAD HASHEMI, “ASSOCIATION BETWEEN A561C POLYMORPHISM OF E-SELECTIN GENE AND CORONARY ARTERIAL DISEASE IN SOUTHEASTERN IRANIAN POPULATION,” HEALTH SCOPE, vol. 2, no. 1, pp. 47–51, 2013, [Online]. Available: https://sid.ir/paper/330342/en

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