مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

WOUND HEALING POTENTIAL OF TOPICAL AMLODIPINE IN FULL THICKNESS WOUND OF RABBIT

Pages

  0-0

Abstract

 Background: WOUND HEALING is a complicated and integrated process. Researches have indicated the WOUND HEALING effects of CALCIUM CHANNEL BLOCKERs in animal models in recent years.Objectives: The aim of this study was to evaluate the wound-healing activity of AMLODIPINE as a CALCIUM CHANNEL BLOCKER and combination of AMLODIPINE with PHENYTOIN on excisional cutaneous wound models in rabbit.Materials and Methods: Animals were divided into 5 groups (n=5). The control group was treated topically with eucerin. The untreated control group received no healing agent. The reference standard group was treated with PHENYTOIN 1%. A treatment group was treated with AMLODIPINE 1%. The last group was treated with combination of AMLODIPINE 1% and PHENYTOIN 1%.Results: Results indicated significant difference between days needed for complete healing in both of the treatment groups. Wound closure was completed on 13th day and 9th day in AMLODIPINE and combination groups respectively.Conclusions: In conclusion, CALCIUM CHANNEL BLOCKERs can be used to enhance WOUND HEALING, especially if this treatment becomes with PHENYTOIN. Further studies are needed to find out the mechanism of this healing effect.

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    APA: Copy

    HEMMATI, ALI ASGHAR, MOJIRI FORUSHANI, HODA, & MOHAMMAD ASGARI, HOSSEIN. (2014). WOUND HEALING POTENTIAL OF TOPICAL AMLODIPINE IN FULL THICKNESS WOUND OF RABBIT. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, 9(3), 0-0. SID. https://sid.ir/paper/331351/en

    Vancouver: Copy

    HEMMATI ALI ASGHAR, MOJIRI FORUSHANI HODA, MOHAMMAD ASGARI HOSSEIN. WOUND HEALING POTENTIAL OF TOPICAL AMLODIPINE IN FULL THICKNESS WOUND OF RABBIT. JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS[Internet]. 2014;9(3):0-0. Available from: https://sid.ir/paper/331351/en

    IEEE: Copy

    ALI ASGHAR HEMMATI, HODA MOJIRI FORUSHANI, and HOSSEIN MOHAMMAD ASGARI, “WOUND HEALING POTENTIAL OF TOPICAL AMLODIPINE IN FULL THICKNESS WOUND OF RABBIT,” JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS, vol. 9, no. 3, pp. 0–0, 2014, [Online]. Available: https://sid.ir/paper/331351/en

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