ESMOLOL: A UNIQUE BETA-BLOCKER IN MAINTAINING CARDIOVASCULAR STABILITY FOLLOWING NEUROSURGICAL PROCEDURES

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HOSSEINZADEH HAMZEH; EYDI MAHMOUD; GHAFFARLOU MEHDI; GHABILI KAMYAR; GOLZARI SAMAD E.J.

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Journal: Advanced Pharmaceutical Bulletin Year:2012 | Volume:2 | Issue:2 Page(s): 249-252

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Title

ESMOLOL: A UNIQUE BETA-BLOCKER IN MAINTAINING CARDIOVASCULAR STABILITY FOLLOWING NEUROSURGICAL PROCEDURES

Author(s)

Keywords

ESMOLOL

NEUROSURGERY

CARDIOVASCULAR STABILITY

Abstract

Purpose: Patients with increased intracranial pressure (ICP) are prone to severe cardiac and or cerebral complications following emergence from general anesthesia and especially post-extubation phase. Administering beta blockers including ESMOLOL is believed to be helpful in providing a stable hemodynamic at the end of the surgery and recovery stages and reducing recovery phase length.Methods: In a double-blind prospective randomized clinical trial, 60 adult patients with ASA (American Society of Anesthesiologist) class of I-II scheduled to undergo elective NEUROSURGERY operations were randomly divided into two groups receiving ESMOLOL (n=30) and placebo (n=30) as IV infusion within four minutes prior to extubation continued by an IV infusion for 10 minutes after extubation.Results: There was a significant difference between two groups regarding the changes of systolic blood pressure and heart rate at all studied stages after extubation (P£0.05). However, no significant difference existed between ESMOLOL and control groups regarding recovery and extubation times emphasizing the fact that ESMOLOL is of excellent early recovery and extubation profiles.Conclusion: ESMOLOL is advised to be used in preventing hyperdynamic status throughout extubation phase without extending recovery phase length.

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APA: Copy

HOSSEINZADEH, HAMZEH, EYDI, MAHMOUD, GHAFFARLOU, MEHDI, GHABILI, KAMYAR, & GOLZARI, SAMAD E.J.. (2012). ESMOLOL: A UNIQUE BETA-BLOCKER IN MAINTAINING CARDIOVASCULAR STABILITY FOLLOWING NEUROSURGICAL PROCEDURES. ADVANCED PHARMACEUTICAL BULLETIN, 2(2), 249-252. SID. https://sid.ir/paper/331652/en

Vancouver: Copy

HOSSEINZADEH HAMZEH, EYDI MAHMOUD, GHAFFARLOU MEHDI, GHABILI KAMYAR, GOLZARI SAMAD E.J.. ESMOLOL: A UNIQUE BETA-BLOCKER IN MAINTAINING CARDIOVASCULAR STABILITY FOLLOWING NEUROSURGICAL PROCEDURES. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2012;2(2):249-252. Available from: https://sid.ir/paper/331652/en

IEEE: Copy

HAMZEH HOSSEINZADEH, MAHMOUD EYDI, MEHDI GHAFFARLOU, KAMYAR GHABILI, and SAMAD E.J. GOLZARI, “ESMOLOL: A UNIQUE BETA-BLOCKER IN MAINTAINING CARDIOVASCULAR STABILITY FOLLOWING NEUROSURGICAL PROCEDURES,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 2, no. 2, pp. 249–252, 2012, [Online]. Available: https://sid.ir/paper/331652/en

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