LACTOSE ENGINEERING FOR BETTER PERFORMANCE IN DRY POWDER INHALERS

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RAHIMPOUR YAHYA; HAMISHEHKAR HAMED

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Journal Paper

Paper Information

Journal: Advanced Pharmaceutical Bulletin Year:2012 | Volume:2 | Issue:2 Page(s): 183-187

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Information Journal Paper

Title

LACTOSE ENGINEERING FOR BETTER PERFORMANCE IN DRY POWDER INHALERS

Author(s)

RAHIMPOUR YAHYA | HAMISHEHKAR HAMED | Issue Writer Certificate

Keywords

CARRIER

DRY POWDER INHALER

PULMONARY DRUG DELIVERY

LACTOSE

Abstract

Dry powder inhaler (DPI) is generally formulated as a powder mixture of coarse CARRIER particles and micronized drug with aerodynamic diameters of 1-5 mm. CARRIER particles are used to improve drug particle flowability, thus improving dosing accuracy, minimizing the dose variability compared with drug alone and making them easier to handle during manufacturing operations. LACTOSE is the most common and frequently used CARRIER in DPIs formulations and nowadays various inhalation grades of LACTOSE with different physico-chemical properties are available on the market. Therefore, the purpose of this manuscript is to review evolution of LACTOSE as a CARRIER in inhalable formulations, their production and the impact of its physico-chemical properties on drug dispersion. This review offers a perspective on the current reported studies to modify LACTOSE for better performance in DPIs.

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APA: Copy

RAHIMPOUR, YAHYA, & HAMISHEHKAR, HAMED. (2012). LACTOSE ENGINEERING FOR BETTER PERFORMANCE IN DRY POWDER INHALERS. ADVANCED PHARMACEUTICAL BULLETIN, 2(2), 183-187. SID. https://sid.ir/paper/331666/en

Vancouver: Copy

RAHIMPOUR YAHYA, HAMISHEHKAR HAMED. LACTOSE ENGINEERING FOR BETTER PERFORMANCE IN DRY POWDER INHALERS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2012;2(2):183-187. Available from: https://sid.ir/paper/331666/en

IEEE: Copy

YAHYA RAHIMPOUR, and HAMED HAMISHEHKAR, “LACTOSE ENGINEERING FOR BETTER PERFORMANCE IN DRY POWDER INHALERS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 2, no. 2, pp. 183–187, 2012, [Online]. Available: https://sid.ir/paper/331666/en

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