IONTOPHORETIC PERMEATION OF LISINOPRIL AT DIFFERENT CURRENT DENSITIES AND DRUG CONCENTRATIONS

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JAIN ASHISH; NAYAK SATISH; SONI VANDANA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Advanced Pharmaceutical Bulletin Year:2012 | Volume:2 | Issue:2 Page(s): 239-244

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Information Journal Paper

Title

IONTOPHORETIC PERMEATION OF LISINOPRIL AT DIFFERENT CURRENT DENSITIES AND DRUG CONCENTRATIONS

Author(s)

JAIN ASHISH | NAYAK SATISH | SONI VANDANA | Issue Writer Certificate

Keywords

LISINOPRIL

IONTOPHORESIS

CURRENT DENSITIES

PIGSKIN

TRANSDERMAL DRUG DELIVERY

Abstract

Purpose: The purpose of the present work was to assess iontophoretic permeation of LISINOPRIL at different CURRENT DENSITIES and concentrations for development of patient-controlled active transdermal system.Methods: In vitro iontophoretic transdermal delivery of LISINOPRIL across the PIGSKIN was investigated at three different drug concentrations and three different CURRENT DENSITIES (0.25- 0.75 mA/cm2) in the donor cell of the diffusion apparatus, using cathodal IONTOPHORESIS along with the passive controls.Results: For passive permeation, the steady state flux significantly increased with the increasing of donor drug concentration. At all concentration levels, IONTOPHORESIS considerably increased the permeation rate compared to passive controls. Iontophoretic transport of LISINOPRIL was to be found increase with CURRENT DENSITIES. Flux enhancement was highest at the lowest drug load and lowest at the highest drug load.Conclusion: The obtained results indicate that permeation rate of LISINOPRIL across the PIGSKIN can be considerably enhanced, controlled or optimized by the use of IONTOPHORESIS technique.

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APA: Copy

JAIN, ASHISH, NAYAK, SATISH, & SONI, VANDANA. (2012). IONTOPHORETIC PERMEATION OF LISINOPRIL AT DIFFERENT CURRENT DENSITIES AND DRUG CONCENTRATIONS. ADVANCED PHARMACEUTICAL BULLETIN, 2(2), 239-244. SID. https://sid.ir/paper/331668/en

Vancouver: Copy

JAIN ASHISH, NAYAK SATISH, SONI VANDANA. IONTOPHORETIC PERMEATION OF LISINOPRIL AT DIFFERENT CURRENT DENSITIES AND DRUG CONCENTRATIONS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2012;2(2):239-244. Available from: https://sid.ir/paper/331668/en

IEEE: Copy

ASHISH JAIN, SATISH NAYAK, and VANDANA SONI, “IONTOPHORETIC PERMEATION OF LISINOPRIL AT DIFFERENT CURRENT DENSITIES AND DRUG CONCENTRATIONS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 2, no. 2, pp. 239–244, 2012, [Online]. Available: https://sid.ir/paper/331668/en

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