مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

DIVERSITY OF HELICOBACTER PYLORI CAGA AND VACA GENES AND ITS RELATIONSHIP WITH CLINICAL OUTCOMES IN AZERBAIJAN, IRAN

Pages

  57-62

Abstract

 Purpose: The purpose of this research was to analyze cag A and vac A genotypes status in H. PYLORI isolates and relationship with clinical outcomes.Methods: Gastric biopsy specimens were cultured for H. PYLORI isolation and cag A and vac A genes were detected in these isolates. Data were collected and the results were analyzed using c2 and Fishers exact tests by SPSS software version.16.Results: Of the total 115 H. PYLORI isolates, 79 (68.7%) were cag A positive and 82 (71.3%) of isolates contained the s1 allele which 33 (28.7%) were subtype s2. s1m2 was the most frequent vac A allelic combination in the H. PYLORI isolates examined (63 cases), followed by s2m2 (31 cases), s1m1 (19 cases) and s2m1 (2 case). Strains cag A positive were more frequent in peptic ulcer diseases patients than non ulcer diseases patients, as 47 (59.5%) and 32 (40.5%), while cag A negative were low, as 15 (41.7%) and 21 (58.3%), respectively.Conclusion: We found that the cag A and vac A status were not related to clinical outcomes in this area. Overall, in the present study, vac A s1/m2, cag A-positive strains were predominant irrespective of clinical outcome, but s2/m1 was rare.

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    APA: Copy

    GHOTASLOU, REZA, MILANI, MORTEZA, AKHI, MOHAMMAD TAGHI, NAHAEE, MOHAMMAD REZA, HASANI, ALKA, HEJAZI, MOHAMMAD SAEID, & MESHKINI, MOHAMMAD. (2013). DIVERSITY OF HELICOBACTER PYLORI CAGA AND VACA GENES AND ITS RELATIONSHIP WITH CLINICAL OUTCOMES IN AZERBAIJAN, IRAN. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 57-62. SID. https://sid.ir/paper/331670/en

    Vancouver: Copy

    GHOTASLOU REZA, MILANI MORTEZA, AKHI MOHAMMAD TAGHI, NAHAEE MOHAMMAD REZA, HASANI ALKA, HEJAZI MOHAMMAD SAEID, MESHKINI MOHAMMAD. DIVERSITY OF HELICOBACTER PYLORI CAGA AND VACA GENES AND ITS RELATIONSHIP WITH CLINICAL OUTCOMES IN AZERBAIJAN, IRAN. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):57-62. Available from: https://sid.ir/paper/331670/en

    IEEE: Copy

    REZA GHOTASLOU, MORTEZA MILANI, MOHAMMAD TAGHI AKHI, MOHAMMAD REZA NAHAEE, ALKA HASANI, MOHAMMAD SAEID HEJAZI, and MOHAMMAD MESHKINI, “DIVERSITY OF HELICOBACTER PYLORI CAGA AND VACA GENES AND ITS RELATIONSHIP WITH CLINICAL OUTCOMES IN AZERBAIJAN, IRAN,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 57–62, 2013, [Online]. Available: https://sid.ir/paper/331670/en

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