مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

279
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

190
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

THE EFFECTS OF LYOPHILIZATION ON THE PHYSICO-CHEMICAL STABILITY OF SIROLIMUS LIPOSOMES

Pages

  25-29

Abstract

 Purpose: The major limitation in the widespread use of LIPOSOME drug delivery system is its instability. LYOPHILIZATION is a promising approach to ensure the long-term STABILITY of LIPOSOMEs. The aim of this study was to prepare SIROLIMUS-loaded LIPOSOMEs, study their STABILITY and investigate the effect of LYOPHILIZATION either in the presence or in the absence of lyoprotectant on LIPOSOME properties.Methods: Two types of multi-lamellar LIPOSOMEs, conventional and fusogenic, containing SIROLIMUS were prepared by modified thin film hydration method with different ratio of dipalmitoylphosphatidylcholine (DPPC), cholesterol and dioleoylphosphoethanolamine (DOPE), and were lyophilized with or without dextrose as lyoprotectant. Chemical STABILITY investigation was performed at 4oC and 25oC until 6 months using a validated HPLC method. Physical STABILITY was studied with determination of particle size (PS) and encapsulation efficiency (EE%) of formulations through 6 months.Results: Chemical STABILITY test at 4oC and 25oC until 6 months showed that drug content of LIPOSOMEs decreased 8.4% and 20.2% respectively. Initial mean EE% and PS were 72.8% and 582 nm respectively. After 6 months mean EE% for suspended form, lyophilized without lyoprotectant and lyophilized with lyoprotectant were 54.8%, 62.3% and 67.1% at 4oC and 48.2%, 60.4% and 66.8% at 25oC respectively. Corresponding data for mean PS were 8229 nm, 2397 nm and 688nm at 4oC and 9362 nm, 1944 nm and 737 nm at 25oC respectively.Conclusion: It is concluded that LYOPHILIZATION with and without dextrose could increase shelf life of LIPOSOME and dextrose has lyoprotectant effect that stabilized LIPOSOMEs in the LYOPHILIZATION process.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    GHANBARZADEH, SAEED, VALIZADEH, HADI, & ZAKERI MILANI, PARVIN. (2013). THE EFFECTS OF LYOPHILIZATION ON THE PHYSICO-CHEMICAL STABILITY OF SIROLIMUS LIPOSOMES. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 25-29. SID. https://sid.ir/paper/331684/en

    Vancouver: Copy

    GHANBARZADEH SAEED, VALIZADEH HADI, ZAKERI MILANI PARVIN. THE EFFECTS OF LYOPHILIZATION ON THE PHYSICO-CHEMICAL STABILITY OF SIROLIMUS LIPOSOMES. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):25-29. Available from: https://sid.ir/paper/331684/en

    IEEE: Copy

    SAEED GHANBARZADEH, HADI VALIZADEH, and PARVIN ZAKERI MILANI, “THE EFFECTS OF LYOPHILIZATION ON THE PHYSICO-CHEMICAL STABILITY OF SIROLIMUS LIPOSOMES,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 25–29, 2013, [Online]. Available: https://sid.ir/paper/331684/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button