مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

259
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

115
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

DOSE-DEPENDENT EFFECT OF FLOUXETINE ON 6-OHDA-INDUCED CATALEPSY IN MALE RATS: A POSSIBLE INVOLVEMENT OF 5-HT1A RECEPTORS

Pages

  203-206

Abstract

 Purpose: Progressive loss of dopaminergic neurons of the substantia nigra pars compacta (SNc) in Parkinson’s disease (PD) leads to impairment of motor skills. Several evidences show that the role of serotonergic system in regulation of normal movement is pivotal and mediates via 5-HT1A receptors. Our previous study has shown that FLUOXETINE in acute injections able to attenuate CATALEPSY in 6-HYDROXYDOPAMINE (6-OHDA) -lesioned RATs. Since drugs are used chronically in clinic, in this study we attempted to evaluate effect of chronic administration of FLUOXETINE on 6-OHDA-induced CATALEPSY.Methods: CATALEPSY was induced by unilateral infusion of 6-OHDA (8 mg/2 ml/rat) into the central region of SNc and assayed by using bar-test. FLUOXETINE (1, 2.5, 5 and 10 mg/kg) was injected intraperitonealy (ip) for 10 days and its anti-cataleptic effect was assessed at the 10th day.Results: FLUOXETINE in high doses (5 and 10 mg/kg) worsened 6-OHDA-induced CATALEPSY while it had anti-cataleptic effect at the dose of 1 mg/kg. The anti-cataleptic effect of FLUOXETINE (1mg/kg) was reversed by co-administration with NAN-190 (0.5 mg/kg, ip), as a5-HT1A receptor antagonist.Conclusion: According to the results it can be concluded that FLUOXETINE has anti-cataleptic effect in parkinsonian RATs only at low doses, whereas at higher doses it worsens CATALEPSY. It’s anti-cataleptic effect is exerted through affecting on 5-HT1A receptors. However, at high doses other mechanisms may be involved. Further clinical studies are needed to prove it’s possible clinical application as an adjuvant therapy in reducing CATALEPSY of PD.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    SHARIFI, HAMDOLAH, MOHAJJEL NAYEBI, ALIREZA, & FARAJNIA, SAFAR. (2013). DOSE-DEPENDENT EFFECT OF FLOUXETINE ON 6-OHDA-INDUCED CATALEPSY IN MALE RATS: A POSSIBLE INVOLVEMENT OF 5-HT1A RECEPTORS. ADVANCED PHARMACEUTICAL BULLETIN, 3(1), 203-206. SID. https://sid.ir/paper/331708/en

    Vancouver: Copy

    SHARIFI HAMDOLAH, MOHAJJEL NAYEBI ALIREZA, FARAJNIA SAFAR. DOSE-DEPENDENT EFFECT OF FLOUXETINE ON 6-OHDA-INDUCED CATALEPSY IN MALE RATS: A POSSIBLE INVOLVEMENT OF 5-HT1A RECEPTORS. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(1):203-206. Available from: https://sid.ir/paper/331708/en

    IEEE: Copy

    HAMDOLAH SHARIFI, ALIREZA MOHAJJEL NAYEBI, and SAFAR FARAJNIA, “DOSE-DEPENDENT EFFECT OF FLOUXETINE ON 6-OHDA-INDUCED CATALEPSY IN MALE RATS: A POSSIBLE INVOLVEMENT OF 5-HT1A RECEPTORS,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 1, pp. 203–206, 2013, [Online]. Available: https://sid.ir/paper/331708/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button