UTILIZATION OF THIN FILM METHOD FOR PREPARATION OF CELECOXIB LOADED LIPOSOMES

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MOGHIMIPOUR ESKANDAR; HANDALI SOMAYEH

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Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2012 | Volume:2 | Issue:1 Page(s): 93-98

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Information Journal Paper

Title

UTILIZATION OF THIN FILM METHOD FOR PREPARATION OF CELECOXIB LOADED LIPOSOMES

Author(s)

MOGHIMIPOUR ESKANDAR | HANDALI SOMAYEH | Issue Writer Certificate

Keywords

CELECOXIB

LIPOSOME

THIN FILM METHOD

DIFFERENTIAL SCANNING CALORIMETER

TRANSMISSION ELECTRON MICROSCOPY

PARTICLE SIZE

Abstract

Purpose: CELECOXIB is nonsteroiddal anti-inflammatory drug that has been used extensively to treat patients with arthritis. The aim of the present study was to formulate and characterize liposomal vesicles loaded with CELECOXIB.Methods: LIPOSOMEs were prepared by THIN FILM METHOD using soya lecithin and cholesterol. The release of drug was determined using a dialysis membrane method. LIPOSOMEs were characterized by DIFFERENTIAL SCANNING CALORIMETERy (DSC), TRANSMISSION ELECTRON MICROSCOPY (TEM) and their PARTICLE SIZE was also determined.Results: The results showed that the drug encapsulation efficiency was 67.34% and there was 67.16% release after 0.5, 1, 2, 3, 4, 5, 6, 7, 8 and 24 h. Results of PARTICLE SIZE determination showed a mean size of 677nm and nanoparticles were spherical as shown by TEM. The DSC curve of lecithin, cholesterol and CELECOXIB were different from CELECOXIB containing LIPOSOME.Conclusion: The results of characterization of the vesicles indicated the potential application of CELECOXIB loaded LIPOSOME as carrier system.

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APA: Copy

MOGHIMIPOUR, ESKANDAR, & HANDALI, SOMAYEH. (2012). UTILIZATION OF THIN FILM METHOD FOR PREPARATION OF CELECOXIB LOADED LIPOSOMES. ADVANCED PHARMACEUTICAL BULLETIN, 2(1), 93-98. SID. https://sid.ir/paper/331727/en

Vancouver: Copy

MOGHIMIPOUR ESKANDAR, HANDALI SOMAYEH. UTILIZATION OF THIN FILM METHOD FOR PREPARATION OF CELECOXIB LOADED LIPOSOMES. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2012;2(1):93-98. Available from: https://sid.ir/paper/331727/en

IEEE: Copy

ESKANDAR MOGHIMIPOUR, and SOMAYEH HANDALI, “UTILIZATION OF THIN FILM METHOD FOR PREPARATION OF CELECOXIB LOADED LIPOSOMES,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 2, no. 1, pp. 93–98, 2012, [Online]. Available: https://sid.ir/paper/331727/en

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