SHORT TERM ADMINISTRATION OF L-CARNITINE CAN BE DETRIMENTAL TO THE ISCHEMIC HEART

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NAJAFI MOSLEM; GARJANI ALIREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2014 | Volume:4 | Issue:1 Page(s): 1-3

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Information Journal Paper

Title

SHORT TERM ADMINISTRATION OF L-CARNITINE CAN BE DETRIMENTAL TO THE ISCHEMIC HEART

Author(s)

NAJAFI MOSLEM | GARJANI ALIREZA | Issue Writer Certificate

Keywords

L-CARNITINE

ARRHYTHMIA

ISCHEMIA

REPERFUSION

Abstract

Previous studies have shown that L-CARNITINE (LC) supplementation may exert a cardioprotective effect in cardiomyopathy, prevent ARRHYTHMIAs in myocardial infarction and increase exercise tolerance in angina. Interestingly, we demonstrated that short term preischemic administration of LC can be detrimental to ischemic heart. In isolated rat hearts treated with LC for 10 min before ISCHEMIA, a marked and concentration dependent arrhythmogenic activity were produced during both ISCHEMIA and REPERFUSION as increases in the number of ventricular ectopic beats, ventricular tachycardia and incidence of ventricular fibrillation. We hypothesized that preischemic using of LC for an inadequate time may pose arrhythmogenic activity, due to incomplete metabolism of fatty acids which in turn lead to production of toxic long chain fatty acid metabolites and also because of interruption in glucose oxidation.

Cites

STRUCTURAL CHANGES OF CARDIAC TISSUE IN RESPONSE TO L-CARNITINE SUPPLEMENTATION DURING ENDURANCE TRAINING IN WISTAR MALE RATS TOXICATED BY STEROID ANABOLIC HORMONE

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APA: Copy

NAJAFI, MOSLEM, & GARJANI, ALIREZA. (2014). SHORT TERM ADMINISTRATION OF L-CARNITINE CAN BE DETRIMENTAL TO THE ISCHEMIC HEART. ADVANCED PHARMACEUTICAL BULLETIN, 4(1), 1-3. SID. https://sid.ir/paper/331734/en

Vancouver: Copy

NAJAFI MOSLEM, GARJANI ALIREZA. SHORT TERM ADMINISTRATION OF L-CARNITINE CAN BE DETRIMENTAL TO THE ISCHEMIC HEART. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2014;4(1):1-3. Available from: https://sid.ir/paper/331734/en

IEEE: Copy

MOSLEM NAJAFI, and ALIREZA GARJANI, “SHORT TERM ADMINISTRATION OF L-CARNITINE CAN BE DETRIMENTAL TO THE ISCHEMIC HEART,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 4, no. 1, pp. 1–3, 2014, [Online]. Available: https://sid.ir/paper/331734/en

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