PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND PERFORMANCE EVALUATION OF GOLD NANOPARTICLES IN RADIOTHERAPY

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KAMIAR ALI; GHOTASLOU REZA; VALIZADEH HADI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2013 | Volume:3 | Issue:2 Page(s): 425-428

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Information Journal Paper

Title

PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND PERFORMANCE EVALUATION OF GOLD NANOPARTICLES IN RADIOTHERAPY

Author(s)

KAMIAR ALI | GHOTASLOU REZA | VALIZADEH HADI | Issue Writer Certificate

Keywords

GOLD NANO PARTICLE

DOSE ENHANCEMENT

RADIATION THERAPY

GEL DOSIMETRY

ANTI-BACTERIAL

Abstract

Purpose: The aim of the present study was preparation, physicochemical characterization and performance evaluation of gold nanoparticles (GNPs) in radiotherapy. Another objective was the investigation of ANTI-BACTERIAL efficacy of gold nanoparticle against E. coli clinical strains.Methods: Gold nanoparticles prepared by controlled reduction of an aqueous HAuCl4 solution using Tri sodium citrate. Particle size analysis and Transmission electron microscopy were used for physicochemical characterization. Polymer GEL DOSIMETRY was used for evaluation of the enhancement of absorbed dose. Diffusion method in agar media was used for investigation of ANTI-BACTERIAL effect.Results: Gold nanoparticles synthesized in size range from 57 nm to 346 nm by planning different formulation. Gold nanoparticle in 57 nm size increased radiation dose effectiveness with the magnitude of about 21%. At the concentration of 400 ppm, Nano gold exhibited significant ANTI-BACTERIAL effect against E. coli clinical strains.Conclusion: It is concluded that gold nanoparticles can be applied as dose enhancer in radiotherapy. The Investigation of ANTI-BACTERIAL efficacy showed that gold nanoparticle had significant effect against E. coli clinical strains.

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APA: Copy

KAMIAR, ALI, GHOTASLOU, REZA, & VALIZADEH, HADI. (2013). PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND PERFORMANCE EVALUATION OF GOLD NANOPARTICLES IN RADIOTHERAPY. ADVANCED PHARMACEUTICAL BULLETIN, 3(2), 425-428. SID. https://sid.ir/paper/331779/en

Vancouver: Copy

KAMIAR ALI, GHOTASLOU REZA, VALIZADEH HADI. PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND PERFORMANCE EVALUATION OF GOLD NANOPARTICLES IN RADIOTHERAPY. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(2):425-428. Available from: https://sid.ir/paper/331779/en

IEEE: Copy

ALI KAMIAR, REZA GHOTASLOU, and HADI VALIZADEH, “PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND PERFORMANCE EVALUATION OF GOLD NANOPARTICLES IN RADIOTHERAPY,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 2, pp. 425–428, 2013, [Online]. Available: https://sid.ir/paper/331779/en

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