IN VITRO CYTOTOXIC ACTIVITY OF FOUR PLANTS USED IN PERSIAN TRADITIONAL MEDICINE

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ZARE SHAHNEH FATEMEH; BARADARAN BEHZAD; ORANGI MONA; ZAMANI FATEMEH

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Journal Paper

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Journal: Advanced Pharmaceutical Bulletin Year:2013 | Volume:3 | Issue:2 Page(s): 453-455

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Information Journal Paper

Title

IN VITRO CYTOTOXIC ACTIVITY OF FOUR PLANTS USED IN PERSIAN TRADITIONAL MEDICINE

Author(s)

ZARE SHAHNEH FATEMEH | BARADARAN BEHZAD | ORANGI MONA | ZAMANI FATEMEH | Issue Writer Certificate

Keywords

CYTOTOXIC

ANTI-TUMOR

APOPTOSIS

CANCER

Abstract

Purpose: The aim of this study was to investigate in vitro CYTOTOXIC activity of four methanolic crude plant extracts against panel cell lines.Methods: Methanolic extracts were tested for their possible antitumor activity and CYTOTOXICity using the 3- (4, 5-dimetylthiazol-2-yl) -2, 5- diphenyltetrazolium bromide (MTT) assay on six CANCER cell lines; non-Hodgkin’s B-cell lymphoma (Raji), human leukemic monocyte lymphoma (U937), human acute myelocytic leukemia (KG-1A), human breast carcinoma (MCF-7 cells), human Prostate CANCER (PC3) and mouse fibrosarcoma (WEHI-164) cell lines and one normal cell line; Human Umbilical Vein Endothelial Cells (HUVEC).Results: All species showed dose dependent inhibition of cell proliferation. IC50 values ranging from 25.66±1.2 to 205.11±1.3 mg/ml. The highest CYTOTOXIC activity Chelidonium majus L>Ferulago Angulata DC>Echinophora platyloba DC>Salvia officinalis L, respectively.Conclusion: all extracts demonstrate promising CYTOTOXICity activity as a natural resource for future bio-guided fractionation and isolation of potential antitumor agents.

Cites

ANTIVIRAL AND VIRUCIDAL ACTIVITY OF CHELIDONIUM MAJUS L. EXTRACT COMPARED WITH ACYCLOVIR AGAINST HERPES SIMPLEX VIRUS TYPE 1

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APA: Copy

ZARE SHAHNEH, FATEMEH, BARADARAN, BEHZAD, ORANGI, MONA, & ZAMANI, FATEMEH. (2013). IN VITRO CYTOTOXIC ACTIVITY OF FOUR PLANTS USED IN PERSIAN TRADITIONAL MEDICINE. ADVANCED PHARMACEUTICAL BULLETIN, 3(2), 453-455. SID. https://sid.ir/paper/331789/en

Vancouver: Copy

ZARE SHAHNEH FATEMEH, BARADARAN BEHZAD, ORANGI MONA, ZAMANI FATEMEH. IN VITRO CYTOTOXIC ACTIVITY OF FOUR PLANTS USED IN PERSIAN TRADITIONAL MEDICINE. ADVANCED PHARMACEUTICAL BULLETIN[Internet]. 2013;3(2):453-455. Available from: https://sid.ir/paper/331789/en

IEEE: Copy

FATEMEH ZARE SHAHNEH, BEHZAD BARADARAN, MONA ORANGI, and FATEMEH ZAMANI, “IN VITRO CYTOTOXIC ACTIVITY OF FOUR PLANTS USED IN PERSIAN TRADITIONAL MEDICINE,” ADVANCED PHARMACEUTICAL BULLETIN, vol. 3, no. 2, pp. 453–455, 2013, [Online]. Available: https://sid.ir/paper/331789/en

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